Can a new surgical stitch keep Crohn's disease at bay?
NCT ID NCT07772037
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study looks at tissue samples from people with Crohn's disease who had bowel surgery, comparing two ways surgeons reconnect the intestine: the newer Kono-S technique and the standard method. The goal is to see if differences in a protective protein called GPX4, which helps shield cells from damage, explain why Crohn's disease often returns near the surgical join. By examining archived samples from 25 patients, researchers hope to uncover clues that could help surgeons pick the best technique and reduce the chance of disease coming back.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Surgical technique: Kono-S anastomosis versus conventional anastomosis
- What this could lead to
- If successful, this could help surgeons choose the best bowel-joining technique for each Crohn's patient and guide new treatments to improve healing and reduce disease recurrence.
- What could go wrong
- This is a small, retrospective pilot study, so findings may not apply broadly. It looks at tissue markers, not direct patient outcomes, and cannot prove cause and effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 25 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Nov 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Crohn's disease undergoing ileocolic resection, for whom suitable archived histopathology material and relevant clinical data are available.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria:• Adults (≥18 years) with confirmed Crohn's disease who underwent ileocolic or small bowel resection with a primary anastomosis. * Documented anastomotic configuration (Kono-S or conventional). * Availability of archived pathology material from the resection specimen containing the anastomotic site. * At least one additional tissue timepoint available: preoperative endoscopic biopsy or follow up endoscopic biopsy within 24 months. * Available postoperative endoscopic follow up data (Rutgeerts score) where applicable. Exclusion Criteria: * • Indeterminate colitis or non-Crohn's pathology on histology. * Lack of retrievable tissue or poor tissue quality (e.g., extensive necrosis or autolysis) precluding IHC. * Unclear anastomotic type. * Absence of epithelial component in the available tissue (e.g., only serosa or fibrofatty tissue). * Major confounders that could affect GPX4 expression, such as severe ischaemia, uncontrolled sepsis, or immediate reoperation at the anastomotic site. * Patients with permanent stomas and no anastomotic follow up where interpretation would be ambiguous.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Queen Elizabeth the Queen Mother Hospital
Margate, Kent, CT9 4AN, United Kingdom
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