New eye injection aims to halt diabetic vision loss

NCT ID NCT06321302

First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 7 times

Summary

This study tests an experimental drug called BI 764524, given as an eye injection, in 190 adults with moderate to severe diabetic retinopathy. Participants receive different numbers of injections over a year, and doctors compare eye damage improvements against a sham procedure or an existing drug (aflibercept). The goal is to see if BI 764524 can safely improve the condition and prevent vision-threatening complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
BI 764524 (eye injection)
What this could lead to
If it works, this could provide a new treatment option to slow or improve diabetic retinopathy and reduce the risk of vision loss.
What could go wrong
This is an early Phase 2 trial with only 190 participants, so results may not confirm effectiveness. The treatment involves eye injections, which carry risks like infection or inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Akita University Hospital

    Akita, 010-8543, Japan

  • Associated Retina Consultants, Ltd.

    Phoenix, Arizona, 85020, United States

  • Austin Clinical Research, LLC

    Austin, Texas, 78750, United States

  • Austin Retina Associates

    Austin, Texas, 78705, United States

  • Austin Retina Associates

    Round Rock, Texas, 78681, United States

  • Azienda Ospedaliera Universitaria "Federico II"

    Naples, 80131, Italy

  • Azienda Ospedaliero Universitaria Careggi

    Florence, 50134, Italy

  • Bay Area Retina Associates - Walnut Creek

    Walnut Creek, California, 94598, United States

  • Budapest Retina Associations Kft.

    Budapest, 1133, Hungary

  • Byers Eye Institute

    Palo Alto, California, 94303, United States

  • California Eye Specialists Medical Group Inc

    Pasadena, California, 91107, United States

  • California Retina Consultants-Bakersfield-65523

    Bakersfield, California, 93309, United States

  • California Retina Consultants-Santa Maria-65510

    Santa Maria, California, 93454, United States

  • Center for Retina and Macular Disease

    Winter Haven, Florida, 33880, United States

  • Central Middlesex Hospital

    London, United Kingdom

  • Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o.

    Olsztyn, 10-424, Poland

  • Centrum Medyczne Piasta 47 sp. z o.o.

    Wałbrzych, 58-304, Poland

  • Charleston Neuroscience Institute - Ladson

    Ladson, South Carolina, 29456, United States

  • Colchester Hospital

    Colchester, CO4 5JL, United Kingdom

  • Colorado Retina Associates

    Lakewood, Colorado, 80228, United States

  • Cumberland Valley Retina Consultants

    Hagerstown, Maryland, 21740, United States

  • Deep Blue Retina Clinical Research PLLC

    Southaven, Mississippi, 38671, United States

  • Diakonie Klinikum Dietrich Bonhoeffer GmbH

    Neubrandenburg, 17036, Germany

  • East Florida Eye Institute

    Stuart, Florida, 34994, United States

  • Emanuelli Research & Development Center

    Arecibo, 00612, Puerto Rico

  • EyeHealth Northwest

    Portland, Oregon, 97225, United States

  • Florida Retina Consultants

    Lakeland, Florida, 33805, United States

  • Florida Retina Institute

    Jacksonville, Florida, 32216, United States

  • Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fukushima Medical University Hospital

    Fukushima, 960-1295, Japan

  • Hayashi Eye Hospital

    Fukuoka, 812-0011, Japan

  • Hospital General Universitario de Valencia

    Valencia, 46014, Spain

  • Hospital Universitari General de Catalunya

    Sant Cugat Del Vallés, 08195, Spain

  • Hospital Universitari de Bellvitge

    Barcelon, 08907, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hyogo College of Medicine Hospital

    Nishinomiya, 663-8501, Japan

  • Hyogo Prefectural Amagasaki General Medical Center

    Amagasaki-shi, 660-8550, Japan

  • Istituto Clinico Humanitas

    Rozzano, 20089, Italy

  • Jahn Ferenc Del-Pest Hospital

    Budapest, 1204, Hungary

  • Juntendo University Hospital

    Tokyo, 113-8431, Japan

  • Kagawa University Hospital

    Kagawa, Kita-gun, 761-0793, Japan

  • Klinika Okulistyczna

    Bydgoszcz, 85-631, Poland

  • Kobe University Hospital

    Kobe, 650-0017, Japan

  • Long Island Vitreoretinal Consultants

    Great Neck, New York, 11021, United States

  • Lugene Eye Institute

    Glendale, California, 91204, United States

  • Maine Eye Center

    Portland, Maine, 04101, United States

  • Medical Center Ophthalmology Associates

    San Antonio, Texas, 78240, United States

  • Moorfields Eye Hospital

    London, EC1V 2PD, United Kingdom

  • NJRetina

    Teaneck, New Jersey, 07666, United States

  • Nara Medical University Hospital

    Kashihara, 634-8522, Japan

  • National Hospital Organization Tokyo Medical Center

    Meguro-ku, 152-8902, Japan

  • Nozologen Kft.

    Pécs, 7621, Hungary

  • Ospedale San Raffaele S.r.l.

    Milan, 20132, Italy

  • Ospedali Riuniti di Ancona

    Torrette Di Ancona, 60123, Italy

  • Retina Associates of Southern California

    Huntington Beach, California, 92647, United States

  • Retina Associates of Utah

    Salt Lake City, Utah, 84107, United States

  • Retina Consultants Of Hawaii

    ‘Aiea, Hawaii, 96701, United States

  • Retina Consultants of Texas

    Katy, Texas, 77494, United States

  • Retina Consultants of Texas

    San Antonio, Texas, 78240, United States

  • Retina Consultants of Texas - Schertz

    Schertz, Texas, 78154, United States

  • Retina Group of New England, PC

    Waterford, Connecticut, 06385, United States

  • Retina Research Center, PLLC

    Austin, Texas, 78705, United States

  • Retina Vitreous Surgeons of Central NY, PC

    Liverpool, New York, 13088, United States

  • Retina-Vitreous Associates Medical Group

    Beverly Hills, California, 90211, United States

  • Retinal Consultants Medical Group

    Sacramento, California, 95825, United States

  • Retinal Consultants Medical Group

    Sacramento, California, 95841, United States

  • Retinal Diagnostic Center

    Campbell, California, 95008, United States

  • Royal Liverpool University Hospital

    Liverpool, L7 8XP, United Kingdom

  • Royal Victoria Infirmary

    Newcastle upon Tyne, NE1 4LP, United Kingdom

  • Semmelweis University

    Budapest, 1085, Hungary

  • Shinshu University Hospital

    Matsumoto-shi, 390-8621, Japan

  • Tennessee Retina

    Nashville, Tennessee, 37203, United States

  • The Retina Partners

    Encino, California, 91436, United States

  • Tokyo Medical University Hachioji Medical Center

    Hachioji-shi, 193-0998, Japan

  • University Debrecen Hospital

    Debrecen, 4032, Hungary

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • Universitätsklinikum Bonn AöR

    Bonn, 53127, Germany

  • Universitätsklinikum Tübingen

    Tübingen, 72076, Germany

  • Universitätsklinikum Ulm

    Ulm, 89075, Germany

  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Mainz, 55131, Germany

  • Valley Retina Institute, PA

    McAllen, Texas, 78503, United States

  • Warsaw Ophthalmology Hospital

    Warsaw, 01-258, Poland

  • Western Eye Hospital

    London, NW1 5QH, United Kingdom

  • Zala Megyei Szent Rafael Korhaz

    Zala, 8900, Hungary

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