Scientists probe stress hormone link to rare metabolic disease

This study aimed to understand if changes in how the body processes the stress hormone cortisol are involved in Familial Partial Lipodystrophy Type 2 (FPL2), a rare genetic disorder that affects where fat is stored and causes serious metabolic problems. Researchers enrolled 25 adults with a specific genetic mutation for FPL2 to measure cortisol-related markers in their urine and fat tissue. The goal was to gather knowledge about the disease's biology, not to test a treatment.