Cooling down brain injury: new hope for newborns?

NCT ID NCT01192776

First seen Jan 03, 2026 · Last updated May 08, 2026 · Updated 22 times

Summary

This study tested four different cooling methods for newborns who suffered brain injury from lack of oxygen around birth. The goal was to see if longer or deeper cooling could reduce the chance of death or long-term disability. The trial included 364 babies and compared cooling for 72 vs 120 hours at two different temperatures.

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Contacts and locations

Locations

  • Brown University, Women & Infants Hospital of Rhode Island

    Providence, Rhode Island, 02905, United States

  • Case Western Reserve University, Rainbow Babies and Children's Hospital

    Cleveland, Ohio, 44106, United States

  • Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

  • Cincinnati Children's Medical Center

    Cincinnati, Ohio, 45267, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Emory University

    Atlanta, Georgia, 30303, United States

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • RTI International

    Durham, North Carolina, 27705, United States

  • Research Institute at Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • Univeristy of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of California - Los Angeles

    Los Angeles, California, 90025, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • University of Texas Southwestern Medical Center at Dallas

    Dallas, Texas, 75235, United States

  • Wayne State University

    Detroit, Michigan, 48201, United States

Conditions

Explore the condition pages connected to this study.