Can booster drugs keep lymphoma in check after CAR t therapy?

NCT ID NCT05633615

Recruiting now Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding two targeted drugs (mosunetuzumab and/or polatuzumab vedotin) after standard CAR T-cell therapy can help control lymphoma that has returned or not responded to treatment. About 396 adults with certain types of aggressive B-cell lymphoma will be randomly assigned to receive one of these drugs, both, or no extra treatment. The goal is to see if these add-on therapies improve how long the cancer stays under control.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma follicular lymphoma primary mediastinal large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA GRADE 3B FOLLICULAR LYMPHOMA PRIMARY MEDIASTINAL (THYMIC) LARGE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA TRANSFORMED FOLLIC LYMPH TO DIFF LARGE B-CELL LYMPHOMA TRANSFORMED MARG ZONE LYMPH TO DIFF LARGE B-CELL LYMPHOMA

Contacts and locations

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Locations

Atrium Health Cabarrus/LCI-Concord
RECRUITING

Concord, North Carolina, 28025, United States
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Beacon Kalamazoo Cancer Center
RECRUITING

Kalamazoo, Michigan, 49009, United States
Bronson Battle Creek
RECRUITING

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
RECRUITING

Norton Shores, Michigan, 49444, United States
Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States
Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING

Niles, Michigan, 49120, United States
Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States
Dartmouth Cancer Center - North
RECRUITING

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Duke University Medical Center
SUSPENDED

Durham, North Carolina, 27710, United States
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Henry Ford Health Providence Southfield Hospital
ACTIVE_NOT_RECRUITING

Southfield, Michigan, 48075, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States

Contact Email: •••••@•••••
Highlands Oncology Group - Fayetteville
RECRUITING

Fayetteville, Arkansas, 72703, United States

Contact Email: •••••@•••••
Highlands Oncology Group - Rogers
RECRUITING

Rogers, Arkansas, 72758, United States

Contact Email: •••••@•••••
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Loyola University Medical Center
SUSPENDED

Maywood, Illinois, 60153, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
NYP/Weill Cornell Medical Center
SUSPENDED

New York, New York, 10065, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Prisma Health Cancer Institute - Butternut
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley
RECRUITING

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside
RECRUITING

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer
RECRUITING

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca
RECRUITING

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg
RECRUITING

Boiling Springs, South Carolina, 29316, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls
RECRUITING

Twin Falls, Idaho, 83301, United States
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
Trinity Health Grand Rapids Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital
RECRUITING

Muskegon, Michigan, 49444, United States
UC Irvine Health Cancer Center-Newport
RECRUITING

Costa Mesa, California, 92627, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UCI Health Laguna Hills
RECRUITING

Laguna Hills, California, 92653, United States

Contact Email: •••••@•••••
UCSF Medical Center-Parnassus
RECRUITING

San Francisco, California, 94143, United States
UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States

Contact Email: •••••@•••••
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Maryland/Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Wayne State University/Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

Contact Email: •••••@•••••
Weisberg Cancer Treatment Center
RECRUITING

Farmington Hills, Michigan, 48334, United States

Contact Email: •••••@•••••
West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

Contact Email: •••••@•••••

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