Could a simple pill replace IV drips for bleeding ulcers?

NCT ID NCT05582174

Recruiting now Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares an oral medication called Vonoprazan to the standard high-dose IV proton pump inhibitor (PPI) for preventing rebleeding in people with bleeding peptic ulcers after endoscopic treatment. About 594 adults will be randomly assigned to receive either oral Vonoprazan or IV esomeprazole for 72 hours, followed by oral medication for a month. The goal is to see if the oral option works just as well as the IV treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vonoprazan (oral) and esomeprazole (IV and oral)
What this could lead to: If successful, this could offer a simpler, oral-only treatment option to prevent rebleeding after endoscopic treatment for bleeding ulcers, potentially reducing hospital stays.
What could go wrong: This is a phase 4 trial, so the drugs are already approved, but it is still testing a new use. The main risk is that Vonoprazan may not be as effective as the standard IV PPI, leading to more rebleeding episodes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gastrointestinal Hemorrhage peptic ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROTON PUMP INHIBITORS UPPER GI BLEEDING

Contacts and locations

Locations

Nanfang Hospital Southern Medical University
RECRUITING

Guangzhou, Guangdong, China
Prince of Wales Hospital
NOT_YET_RECRUITING

Hong Kong, Hong Kong SAR, China
Shenzhen Pingshan District People's Hospital
NOT_YET_RECRUITING

Shenzhen, Guangdong, China
The Second Affiliated Hospital The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen
NOT_YET_RECRUITING

Shenzhen, Guangdong, China
The Second Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
Yangjiang People's Hospital of Guangdong Medical University
NOT_YET_RECRUITING

Yangjiang, Guangdong, China
Zhuhai People's Hospital (Zhuhai Hospital Affiliated to Jinan University)
NOT_YET_RECRUITING

Zhuhai, Guangdong, China

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