New drug combo battle: which works better for blood cancer?

NCT ID NCT05057494

First seen Nov 17, 2025 · Last updated May 20, 2026 · Updated 24 times

Summary

This study compares two drug combinations for people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. About 600 participants will receive either acalabrutinib plus venetoclax or venetoclax plus obinutuzumab. The goal is to see which combination better controls the disease and reduces cancer cells in the blood.

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Contacts and locations

Locations

  • Research Site

    Tucson, Arizona, 85710, United States

  • Research Site

    La Jolla, California, 92093-0052, United States

  • Research Site

    Longmont, Colorado, 80501, United States

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    Jacksonville, Florida, 32256, United States

  • Research Site

    Boston, Massachusetts, 02115, United States

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    Rochester, Minnesota, 55905, United States

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    St Louis, Missouri, 63110, United States

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    Buffalo, New York, 14263, United States

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    New Hyde Park, New York, 11040, United States

  • Research Site

    New York, New York, 10065, United States

  • Research Site

    Rochester, New York, 14642, United States

  • Research Site

    Charlotte, North Carolina, 28204, United States

  • Research Site

    Cleveland, Ohio, 44195, United States

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    Eugene, Oregon, 97401, United States

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    Nashville, Tennessee, 37203, United States

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    Salt Lake City, Utah, 84112, United States

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    Charlottesville, Virginia, 22908, United States

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    Seattle, Washington, 98104, United States

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    Seattle, Washington, 98109, United States

  • Research Site

    Clayton, 3168, Australia

  • Research Site

    Nedlands, 6009, Australia

  • Research Site

    Waratah, 2298, Australia

  • Research Site

    Hradec Králové, 500 05, Czechia

  • Research Site

    Ostrava - Poruba, 708 52, Czechia

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    Pilsen, 30460, CZ, Czechia

  • Research Site

    Montpellier, 34295, France

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    Tours, 37044, France

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    Budapest, 1097, Hungary

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    Debrecen, 4032, Hungary

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    Bydgoszcz, 85-168, Poland

  • Research Site

    Gdansk, 80-219, Poland

  • Research Site

    Katowice, 40-519, Poland

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    Krakow, 30-727, Poland

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    Lódz, 93-513, Poland

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    Lublin, 20-090, Poland

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    Barcelona, 08025, Spain

  • Research Site

    Palma de Mallorca, 07010, Spain

Conditions

Explore the condition pages connected to this study.