New drug cocktail aims to wipe out stomach tumors before surgery

NCT ID NCT07151209

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 28 times

Summary

This study tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy and a targeted therapy (lenvatinib) in 20 people with a specific type of advanced stomach or gastroesophageal junction cancer (MSI-H/dMMR). The goal is to see if this treatment can shrink the tumor enough to allow successful surgery and possibly eliminate all signs of cancer. Participants will receive the drug combination before surgery, and the main measure of success is whether the cancer completely disappears in the removed tissue.

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