New drug combo aims to tackle tough lymphoma cases

NCT ID NCT07197307

Recruiting now Disease control Sponsor: Universität Münster Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests whether combining two drugs, loncastuximab tesirine and epcoritamab, can safely and effectively treat people with aggressive B-cell lymphoma that has come back or not responded to prior therapy. The trial will include 120 adults who have either not had CAR-T cell therapy or whose lymphoma progressed after CAR-T cells. The main goal is to see how many patients achieve a complete or partial remission within 12 months of starting treatment.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGGRESSIVE DIFFUSE LARGE B-CELL LYMPHOMA FOLLICULAR LYMPHOMA (FL) GRADE 3B HIGH-GRADE B-CELL LYMPHOMA (HGBL)

Contacts and locations

Locations

Charite Universitaetsmedizin Berlin
RECRUITING

Berlin, 12203, Germany
Diakonie-Klinikum Stuttgart Diakonissenkrankenhaus und Paulinenhilfe
NOT_YET_RECRUITING

Stuttgart, 70176, Germany
Evangelisches Klinikum Bethel
RECRUITING

Bielefeld, 33611, Germany
HELIOS Klinikum Berlin-Buch
RECRUITING

Berlin, 13125, Germany
Kliniken Ostalb gemeinnuetzige kommunale Anstalt des oeffentlichen Rechts
RECRUITING

Mutlangen, 73557, Germany
Klinikum Chemnitz
RECRUITING

Chemnitz, 09116, Germany
Klinikum Oldenburg
RECRUITING

Oldenburg, 26133, Germany
Klinikum der Universitaet Muenchen
NOT_YET_RECRUITING

München, 81377, Germany
Medical Center - University Of Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
Medizinisches Versorgungszentrum des Bruederkrankenhauses St. Josef Paderborn
RECRUITING

Paderborn, 33098, Germany
Muehlenkreiskliniken
RECRUITING

Minden, 32429, Germany
Ortenau Klinikum
RECRUITING

Offenburg, 77654, Germany
Philipps-Universitaet Marburg
RECRUITING

Marburg, 35043, Germany
St. Barbara-Klinik Hamm
RECRUITING

Hamm, 59073, Germany
Staedtisches Klinikum Karlsruhe
RECRUITING

Karlsruhe, 76133, Germany
Universitaet Des Saarlandes
RECRUITING

Homburg, 66421, Germany
Universitaetsklinikum Aachen
RECRUITING

Aachen, 52074, Germany
Universitaetsklinikum Augsburg
RECRUITING

Augsburg, 86156, Germany
Universitaetsklinikum Duesseldorf
RECRUITING

Düsseldorf, 40225, Germany
Universitaetsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Essen
NOT_YET_RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Frankfurt
RECRUITING

Frankfurt, 60590, Germany
Universitaetsklinikum Halle (Saale)
RECRUITING

Halle, 06120, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Jena
RECRUITING

Jena, 07747, Germany
Universitaetsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
Universitaetsklinikum Schleswig-Holstein
RECRUITING

Kiel, 24105, Germany
Universitaetsklinikum Schleswig-Holstein
RECRUITING

Lübeck, 23538, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitaetsmedizin Greifswald
RECRUITING

Greifswald, 17489, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
RECRUITING

Mainz, 55131, Germany
University Medical Center Hamburg-Eppendorf
NOT_YET_RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum Münster, Medizinische Klinik A
RECRUITING

Münster, 48149, Germany
Vivantes Netzwerk fuer Gesundheit
RECRUITING

Berlin, 10967, Germany

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