New drug combo shows promise in shrinking head and neck tumors before surgery

NCT ID NCT04848116

First seen Jan 09, 2026 · Last updated May 12, 2026 · Updated 19 times

Summary

This study tests whether giving two drugs—nivolumab and BMS-986253—before surgery can safely shrink tumors in people with head and neck cancer. About 24 adults with HPV-negative squamous cell carcinoma will receive the combination before their planned surgery. The main goals are to check safety and see if the treatment helps reduce the tumor.

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Contacts and locations

Locations

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

Conditions

Explore the condition pages connected to this study.