New combo therapy battles Tough-to-Treat colorectal cancer in major trial
NCT ID NCT05064059
Summary
This study tested whether a new two-drug combination called MK-4280A works better than standard treatments for people with advanced colorectal cancer that has spread and stopped responding to prior therapies. It involved 441 participants whose cancer tested positive for a specific marker (PD-L1). The main goal was to see if the new combination helps people live longer compared to the usual drugs regorafenib or TAS-102.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.O. di Rilievo Nazionale e di alta Specializzazione Garibaldi ( Site 0553)
Catania, 95122, Italy
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ASST Grande Ospedale Metropolitano Niguarda ( Site 0550)
Milan, 20162, Italy
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Acibadem Adana Hastanesi ( Site 1008)
Adana, 01130, Turkey (Türkiye)
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Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 1185)
Wuxi, Jiangsu, 214122, China
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Akershus universitetssykehus ( Site 1352)
Loerenskog, Akershus, 1478, Norway
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Ankara Sehir Hastanesi ( Site 1005)
Ankara, 06800, Turkey (Türkiye)
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Antalya Egitim ve Arastirma Hastanesi ( Site 1010)
Antalya, 07100, Turkey (Türkiye)
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Asan Medical Center ( Site 0650)
Songpagu, Seoul, 05505, South Korea
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Assuta Ashdod Public ( Site 0507)
Ashdod, 7747629, Israel
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Baskent Universitesi Dr. Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 1007)
Adana, 01120, Turkey (Türkiye)
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Beacon Hospital Sdn Bhd ( Site 1305)
Petaling Jaya, Selangor, 46050, Malaysia
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Blue Ridge Cancer Care ( Site 1718)
Roanoke, Virginia, 24014, United States
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Bnei Zion Medical Center ( Site 0506)
Haifa, 3339419, Israel
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Bradfordhill ( Site 0200)
Santiago, Region M. de Santiago, 8420383, Chile
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CHU Bordeaux Haut-Leveque ( Site 0305)
Pessac, Gironde, 33604, France
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CHU Hotel Dieu Nantes ( Site 0303)
Nantes, Pays de la Loire Region, 44093, France
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CHU Poitiers ( Site 0304)
Poitiers, Vienne, 86021, France
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Cancer Care Langenhoven Drive Oncology Centre ( Site 1504)
Port Elizabeth, Eastern Cape, 6045, South Africa
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Cancercare Rondebosch Oncology ( Site 1509)
Rondebosch, Western Cape, 7700, South Africa
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Cape Town Oncology Trials Pty Ltd ( Site 1506)
Kraaifontein, Western Cape, 7570, South Africa
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Centro Investigacion Cancer James Lind ( Site 0204)
Temuco, Región de la Araucanía, 4800827, Chile
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Chaim Sheba Medical Center ( Site 0501)
Ramat Gan, 5262000, Israel
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Chang Gung Medical Foundation - Kaohsiung ( Site 0956)
Kaohsiung City, Changhua, 833, Taiwan
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Chang Gung Medical Foundation. Linkou ( Site 0952)
Taoyuan District, 333, Taiwan
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Changzhou Cancer Hospital-Department of Oncology ( Site 1183)
Changzhou, Jiangsu, 213000, China
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China Medical University Hospital ( Site 0953)
Taichung, 40447, Taiwan
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Chongqing Cancer Hospital ( Site 1151)
Chongqing, Chongqing Municipality, 400030, China
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City Hospital #40 ( Site 0853)
Saint Petersburg, Sankt-Peterburg, 197706, Russia
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Clinica Puerto Montt ( Site 0211)
Port Montt, Los Lagos Region, 5500656, Chile
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Clinical Research Center of specialized types medical care-Oncology ( Site 0860)
Saint Petersburg, Sankt-Peterburg, 197758, Russia
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Clínica Vespucio ( Site 0205)
Santiago, Region M. de Santiago, 8241479, Chile
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Ege Universitesi Tip Fakultesi Hastanesi ( Site 1006)
Izmir, 35100, Turkey (Türkiye)
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FSBI-FRCC of Special Types Med. Care and Technologies FMBA of Russia ( Site 0851)
Moscow, Moscow, 115682, Russia
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Fakultni Thomayerova nemocnice ( Site 1205)
Prague, 140 59, Czechia
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Fakultni nemocnice Hradec Kralove ( Site 1207)
Hradec Králové, 500 05, Czechia
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Fakultni nemocnice Kralovske Vinohrady ( Site 1208)
Prague, 100 34, Czechia
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Fakultni nemocnice Na Bulovce ( Site 1202)
Prague, 180 81, Czechia
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Fakultni nemocnice Olomouc ( Site 1204)
Olomouc, 779 00, Czechia
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Fakultni nemocnice v Motole ( Site 1201)
Prague, Praha, Hlavni Mesto, 150 06, Czechia
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Frankston Hospital ( Site 0056)
Frankston, Victoria, 3199, Australia
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Fudan University Shanghai Cancer Center ( Site 1176)
Shanghai, Shanghai Municipality, 201321, China
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Fujian Province Cancer Hospital ( Site 1178)
Fuzhou, Fujian, 350014, China
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Fundacion Arturo Lopez Perez FALP ( Site 0208)
Santiago, Region M. de Santiago, 7500921, Chile
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Georgetown University Hospital ( Site 1148)
Washington D.C., District of Columbia, 20007, United States
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Goztepe Prof.Dr. Suleyman Yalcin Sehir Hastanesi ( Site 1002)
Istanbul, 34722, Turkey (Türkiye)
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Guangxi Medical University Affiliated Tumor Hospital ( Site 1158)
Nanning, Guangxi, 531021, China
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Gulhane Egitim ve Arastirma Hastanesi ( Site 1009)
Ankara, 06010, Turkey (Türkiye)
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Hacettepe Universitesi Tip Fakultesi ( Site 1003)
Ankara, 06230, Turkey (Türkiye)
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Hadassa Ein Karem Medical Center ( Site 0504)
Jerusalem, 9112001, Israel
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Hainan General Hospital ( Site 1177)
Haikou, Hainan, 570311, China
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Helse Bergen HF - Haukeland univeritetssykehus ( Site 1353)
Bergen, Vestfold, 5053, Norway
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Hopital Europeen Georges Pompidou ( Site 0300)
Paris, 75015, France
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Hospital Clinico San Carlos ( Site 0902)
Madrid, 28040, Spain
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Hospital Sant Pau i la Santa Creu ( Site 0905)
Barcelona, 08041, Spain
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Hospital Universitari Vall d Hebron ( Site 0900)
Barcelona, 08035, Spain
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Hospital Universitario 12 de Octubre ( Site 0901)
Madrid, 28041, Spain
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Hospital Universitario Virgen Macarena ( Site 0906)
Seville, 41009, Spain
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Hubei Cancer Hospital ( Site 1152)
Wuhan, Hubei, 430079, China
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Hunan Cancer Hospital ( Site 1174)
Changsha, Hunan, 410013, China
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IC La Serena Research ( Site 0202)
La Serena, Coquimbo Region, 1720430, Chile
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IRCCS Casa Sollievo della Sofferenza ( Site 0554)
San Giovanni Rotondo, Foggia, 71013, Italy
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Imperial College Healthcare NHS Trust - Hammersmith Hospital ( Site 1052)
London, London, City of, W12 0HS, United Kingdom
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Inova Schar Cancer Institute ( Site 1130)
Fairfax, Virginia, 22031, United States
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Institut Kanser Negara - National Cancer Institute ( Site 1302)
Putrajaya, Putrajaya, 62250, Malaysia
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Institut du Cancer Avignon-Provence ( Site 0306)
Avignon, Vaucluse, 84000, France
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Intermountain Medical Center ( Site 1707)
Murray, Utah, 84107, United States
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Istituto Clinico Humanitas - Cancer Center ( Site 0555)
Rozzano, Milano, 20089, Italy
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Japanese Foundation for Cancer Research ( Site 0602)
Tokyo, 135-8550, Japan
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Jilin Cancer Hospital ( Site 1163)
Changchun, Jilin, 130012, China
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Jinan Central Hospital ( Site 1167)
Jinan, Shandong, 250000, China
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Johanniter Krankenhaus Bonn ( Site 1254)
Bonn, North Rhine-Westphalia, 53113, Germany
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Kagawa University Hospital ( Site 0608)
Kita-gun, Kagawa-ken, 761-0793, Japan
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Katholisches Marienkrankenhaus gGmbH ( Site 1257)
Hamburg, 22087, Germany
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Kindai University Hospital ( Site 0607)
Sayama, Osaka, 5898511, Japan
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Kliniken Maria Hilf GmbH ( Site 1255)
Mönchengladbach, North Rhine-Westphalia, 41063, Germany
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Klinikum Wolfsburg ( Site 1256)
Wolfsburg, Lower Saxony, 38440, Germany
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LMU Klinikum Grosshadern der Universitaet Muenchen ( Site 1253)
Munich, Bavaria, 81377, Germany
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Leeds Teaching Hospitals NHS Trust ( Site 1050)
Leeds, LS9 7TF, United Kingdom
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London Regional Cancer Program - London HSC ( Site 0154)
London, Ontario, N6A 5W9, Canada
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MI Precarpathian Clinical Oncology Center ( Site 1654)
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
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MUSC Hollings Cancer Center ( Site 1715)
Charleston, South Carolina, 29425, United States
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Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 0870)
Moscow, Moscow, 105094, Russia
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Masarykuv onkologicky ustav ( Site 1203)
Brno, Brno-mesto, 656 53, Czechia
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Memorial Sloan Kettering Cancer Center ( Site 1703)
New York, New York, 10065, United States
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Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 1657)
Dnipro, Dnipropetrovsk Oblast, 49102, Ukraine
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National Cancer Center Hospital ( Site 0601)
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East ( Site 0600)
Kashiwa, Chiba, 277-8577, Japan
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National Cheng Kung University Hospital ( Site 0955)
Tainan, 704, Taiwan
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National Hospital Organization Kyushu Cancer Center ( Site 0609)
Fukuoka, 811-1395, Japan
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National Taiwan University Hospital ( Site 0950)
Taipei, 10048, Taiwan
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Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1118)
Marietta, Georgia, 30060, United States
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Norton Cancer Institute ( Site 1139)
Louisville, Kentucky, 40217, United States
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Odessa Regional Clinical Hospital ( Site 1664)
Odesa, Odesa Oblast, 65025, Ukraine
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Oncovida ( Site 0209)
Santiago, Region M. de Santiago, 7510032, Chile
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Oregon Health & Science University ( Site 1141)
Portland, Oregon, 97239, United States
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Oslo Universitetssykehus HF. Ulleval ( Site 1351)
Oslo, 0450, Norway
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Pantai Hospital Kuala Lumpur ( Site 1303)
Bangsar, Kuala Lumpur, 59100, Malaysia
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Philipps-Universitaet Marburg. ( Site 1252)
Marburg, Hesse, 35043, Germany
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Policlinico Gemelli di Roma ( Site 0552)
Roma, Abruzzo, 00168, Italy
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Pontificia Universidad Catolica de Chile ( Site 0206)
Santiago, Region M. de Santiago, 8330032, Chile
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Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0155)
Toronto, Ontario, M5G 2M9, Canada
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Queen Elizabeth Hospital ( Site 0050)
Woodville South, South Australia, 5011, Australia
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Rabin Medical Center ( Site 0503)
Petah Tikva, 4941492, Israel
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Rambam Health Care Campus-Oncology Division ( Site 0500)
Haifa, 3109601, Israel
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Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 0871)
Ufa, Baskortostan, Respublika, 450054, Russia
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Royal Brisbane and Women s Hospital ( Site 0058)
Herston, Queensland, 4029, Australia
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Royal Marsden NHS Foundation Trust ( Site 1064)
London, London, City of, SW3 6JJ, United Kingdom
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Royal Marsden NHS Trust ( Site 1063)
Sutton, London, City of, SM25PT, United Kingdom
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Rutgers Cancer Institute of New Jersey ( Site 1105)
New Brunswick, New Jersey, 08903, United States
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SHBI "Leningrad Regional Clinical Oncology Dispensary n.a. L.D. Roman"-Clinical Trials Department (
Saint Petersburg, 188663, Russia
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SRBHI of Kirov Region Center of Oncology and medical radiology ( Site 0854)
Kirov, Kirov Oblast, 105094, Russia
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Saitama Prefectural Cancer Center ( Site 0603)
Kitaadachi-gun, Saitama, 362-0806, Japan
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Samsung Medical Center ( Site 0651)
Seoul, 06351, South Korea
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Sandton Oncology Medical Group PTY LTD ( Site 1501)
Sandton, Gauteng, 2196, South Africa
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Seattle Cancer Care Alliance ( Site 1107)
Seattle, Washington, 98109, United States
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Seoul National University Hospital ( Site 0653)
Seoul, 03080, South Korea
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Severance Hospital ( Site 0652)
Seoul, 03722, South Korea
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Shanghai Tenth People's Hospital ( Site 1170)
Shanghai, Shanghai Municipality, 200072, China
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Shizuoka Cancer Center ( Site 0605)
Sunto-gun,, Shizuoka, 411-8777, Japan
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Sibley Memorial Hospital ( Site 1143)
Washington D.C., District of Columbia, 20016, United States
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Sir Run Run Shaw Hospital-Medical Oncology ( Site 1173)
Hangzhou, Zhejiang, 310018, China
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Sourasky Medical Center ( Site 0502)
Tel Aviv, 6423906, Israel
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Southern Medical University Nanfang Hospital ( Site 1154)
Guangzhou, Guangdong, 510515, China
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St John of God Subiaco Hospital ( Site 0051)
Perth, Western Australia, 6008, Australia
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St Olavs Hospital ( Site 1354)
Trondheim, Sor-Trondelag, 7030, Norway
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Sun Yat-Sen University Cancer Center ( Site 1150)
Guangzhou, Guangdong, 510060, China
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Taipei Veterans General Hospital ( Site 0951)
Taipei, 11217, Taiwan
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The Ottawa Hospital ( Site 0151)
Ottawa, Ontario, K1H 8L6, Canada
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The Second Affiliated Hospital of Anhui Medical University ( Site 1179)
Hefei, Anhui, 230601, China
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The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 1159)
Guangzhou, Guangdong, 510655, China
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The Third Xiangya Hospital of Central South University ( Site 1175)
Changsha, Hunan, 410013, China
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The West Clinic, PLLC dba West Cancer Center ( Site 1149)
Germantown, Tennessee, 38138, United States
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Tianjin Medical University Cancer Institute and Hospital ( Site 1161)
Tianjin, Tianjin Municipality, 300060, China
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Tomsk National Research Medical Center of Russian Academy of Sciences ( Site 0872)
Tomsk, Tomsk Oblast, 634045, Russia
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UT Southwestern Medical Center ( Site 1709)
Dallas, Texas, 75390-9063, United States
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Ukrainian Center of Tomotherapy ( Site 1658)
Kropyvnytskyi, Kirovohrad Oblast, 25011, Ukraine
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Universita degli Studi della Campania Luigi Vanvitelli-UOC Oncoematologia ( Site 0556)
Naples, 80131, Italy
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Universitetssykehuset i Nord Norge. ( Site 1355)
Tromsø, Troms, 9019, Norway
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University College London Hospitals NHS Foundation Trust ( Site 1056)
London, Camden, WC1E 6AG, United Kingdom
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University Hospital Coventry & Warwickshire ( Site 1062)
Coventry, Warwickshire, CV2 2DX, United Kingdom
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University Malaya Medical Centre ( Site 1301)
Kuala Lumpur, 59100, Malaysia
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Universitätsklinikum Halle ( Site 1251)
Halle, Saxony-Anhalt, 06120, Germany
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VCU Health Adult Outpatient Pavillion ( Site 1712)
Richmond, Virginia, 23219, United States
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Velindre Cancer Centre ( Site 1058)
Cardiff, United Kingdom
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West China Hospital Sichuan University ( Site 1172)
Chengdu, Sichuan, 332001, China
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Western Health-Sunshine & Footscray Hospitals ( Site 0052)
St Albans, Victoria, 3021, Australia
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Westmead Hospital ( Site 0057)
Westmead, New South Wales, 2145, Australia
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Wuhan Union Hospital Cancer Center ( Site 1162)
Wuhan, Hubei, 430022, China
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Xiangya Hospital Central South University ( Site 1171)
Changsha, Hunan, 410008, China
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Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 0850)
Yaroslavl, Yaroslavl Oblast, 150054, Russia
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Yunnan Province Cancer Hospital-Colorectal surgery ( Site 1169)
Kunming, Yunnan, 650106, China
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Zhejiang Cancer Hospital ( Site 1180)
Hangzhou, Zhejiang, 310005, China
Conditions
Explore the condition pages connected to this study.