New hope for Tough-to-Treat colon cancer: major trial tests promising drug combo

NCT ID NCT06750094

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is comparing a new drug combination to the current standard treatment for advanced colorectal cancer that has returned or spread after initial chemotherapy. It aims to see if adding the drug amivantamab to a common chemotherapy regimen helps patients live longer without their cancer getting worse. The trial will enroll about 700 adults with a specific genetic profile whose cancer has progressed despite prior treatment.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AZ Maria Middelares
RECRUITING

Ghent, 9000, Belgium
Actualidad Basada En La Investigacion Del Cancer
RECRUITING

Guadalajara, 44680, Mexico
Adana City Hospital
RECRUITING

Adana, 01060, Turkey (Türkiye)
AdventHealth Cancer Institute
RECRUITING

Orlando, Florida, 32804, United States
Aichi Cancer Center
RECRUITING

Nagoya, 464 8681, Japan
Alliance Cancer Specialists at Main Line
RECRUITING

Penn Wynne, Pennsylvania, 19096, United States
Ankara Bilkent Sehir Hastanesi
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Antoni van Leeuwenhoek
RECRUITING

Amsterdam, 1066 CX, Netherlands
Arizona Oncology Associates PC NAHOA
RECRUITING

Prescott, Arizona, 86301, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Asian Institute Of Gastroenterology
RECRUITING

Hyderabad, 500032, India
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia
RECRUITING

Vitória, 29043 260, Brazil
Assuta MC
RECRUITING

Tel Aviv, 69710, Israel
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
Az Groeninge
RECRUITING

Kortrijk, 8500, Belgium
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
Azienda Sanitaria Universitaria Friuli Centrale ASU FC
RECRUITING

Udine, 33100, Italy
B P Poddar Hospital and Medical research Limited
RECRUITING

Kolkata, 700053, India
Bakirkoy Training and Research Hospital
RECRUITING

Istanbul, 34147, Turkey (Türkiye)
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Beijing Friendship Hospital Capital Medical University
RECRUITING

Beijing, 100050, China
Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku
RECRUITING

Bialystok, 15 027, Poland
Birmingham Heartlands Hospital
RECRUITING

Birmingham, B9 5ST, United Kingdom
CBCC Global Research
RECRUITING

Bakersfield, California, 93309, United States
CHU De Poitiers
RECRUITING

Poitiers, 86000, France
COI Centro Oncologico Internacional Tijuana
RECRUITING

Tijuana, 22010, Mexico
Cancer And Hematology Centers of Western Michigan PC
RECRUITING

Grand Rapids, Michigan, 49503, United States
Cancer and Blood Specialty Clinic
RECRUITING

Los Alamitos, California, 90720, United States
Castle Hill Hospital
RECRUITING

Hull, HU16 5JQ, United Kingdom
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium
Centro Oncologico Personalizado Cope S De R L De C V
RECRUITING

Mexico City, 06760, Mexico
Centro Oncologico de Chihuahua
RECRUITING

Chihuahua City, 31217, Mexico
Centrul Medical Unirea SRL
RECRUITING

Brasov, 500091, Romania
Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 833, Taiwan
Charite Universitatsmedizin Berlin Campus Virchow Klinikum
RECRUITING

Berlin, 13353, Germany
Chiang Mai University
RECRUITING

Chiang Mai, 50200, Thailand
Chiba Cancer Center
RECRUITING

Chiba, 260 0801, Japan
Christian medical
RECRUITING

Vellore, 632004, India
Clinica Univ. de Navarra
RECRUITING

Pamplona, 31008, Spain
Clinica de Oncologie Sf Nectarie
RECRUITING

Craiova, 200542, Romania
Concord Hospital
RECRUITING

Concord, 2139, Australia
Cuidados Oncologicos
RECRUITING

Querétaro, 76000, Mexico
Deenanath Mangeshkar Hospital and Research Centre
RECRUITING

Pune, 411004, India
Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
ETZ TweeSteden
RECRUITING

Tilburg, 5042 AD, Netherlands
Eastern Connecticut Hematology & Oncology Assoc.
RECRUITING

Norwich, Connecticut, 06360, United States
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Florida Cancer Specialists East
RECRUITING

West Palm Beach, Florida, 33401-3406, United States
Florida Cancer Specialists North Region
RECRUITING

St. Petersburg, Florida, 33701-4553, United States
Florida Cancer Specialists South
RECRUITING

Fort Myers, Florida, 33901, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, 200032, China
Fundacao Antonio Prudente A C Camargo Cancer Center
RECRUITING

São Paulo, 01509 900, Brazil
Fundacao Doutor Amaral Carvalho
RECRUITING

Jaú, 17210 080, Brazil
Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base
RECRUITING

São José do Rio Preto, 15090 000, Brazil
Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo
RECRUITING

São Paulo, 01246 000, Brazil
Fundacao Pio XII
RECRUITING

Barretos, 14780 070, Brazil
Fundacao Universidade de Caxias do Sul
RECRUITING

Caxias do Sul, 95070 560, Brazil
Gabrail Cancer Center
RECRUITING

Canton, Ohio, 44718, United States
Gansu Provincial Cancer Hospital
RECRUITING

Lanzhou, 730050, China
Ganzhou Cancer Hospital
RECRUITING

Ganzhou, 341000, China
Gazi Universitesi Hastanesi
RECRUITING

Ankara, 06560, Turkey (Türkiye)
Grady Memorial Hospital
RECRUITING

Atlanta, Georgia, 30303, United States
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, 519041, China
Gulhane Egitim ve Arastirma Hastanesi
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Hadassah Medical Center
RECRUITING

Jerusalem, 9112001, Israel
Harbin medical university cancer hospital
RECRUITING

Harbin, 150081, China
Hattiesburg Clinic
RECRUITING

Hattiesburg, Mississippi, 39401, United States
Health Pharma Queretaro SA de CV
RECRUITING

Querétaro, 76230, Mexico
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States
Hopital Haut Leveque
RECRUITING

Pessac, 33604, France
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hosp. Clinico Univ. de Valencia
RECRUITING

Valencia, 46010, Spain
Hosp. Gral. Univ. Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Hosp. Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hosp. de La Santa Creu I Sant Pau
RECRUITING

Barcelona, 08025, Spain
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Nossa Senhora da Conceicao S A
RECRUITING

Porto Alegre, 91350 200, Brazil
Hospital Pulau Pinang
RECRUITING

George Town, 10450, Malaysia
Hospital Raja Permaisuri Bainun
RECRUITING

Ipoh, 30450, Malaysia
Hospital Santa Izabel Santa Casa de Misericordia da Bahia
RECRUITING

Salvador, 40050 410, Brazil
Hospital Umum Sarawak
RECRUITING

Kuching, 93586, Malaysia
Hospital Universitario Dr Jose Eleuterio Gonzalez
RECRUITING

Monterrey, 64460, Mexico
Hubei Cancer Hospital
RECRUITING

Wuhan, 430079, China
Huizhou Central People's Hospital
RECRUITING

Huizhou, 516001, China
Hunan Cancer hospital
RECRUITING

Changsha, 410013, China
Illinois CancerCare
RECRUITING

Peoria, Illinois, 61615, United States
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Institut Kanser Negara Clinical Research Center
RECRUITING

Putrajaya, 62250, Malaysia
Institut Sainte Catherine
RECRUITING

Avignon, 84918, France
Institutul Oncologic 'Prof Dr. Ion Chiricuta' Cluj-Napoca
RECRUITING

Cluj-Napoca, 400015, Romania
Institutul Regional de Oncologie Iasi
RECRUITING

Iași, 700483, Romania
Instytut Centrum Zdrowia Matki Polki
RECRUITING

Lodz, 93 339, Poland
Ironwood Cancer and Research Center
RECRUITING

Chandler, Arizona, 85224, United States
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Dei Tumori Di Milano
RECRUITING

Milan, 20133, Italy
Istituto Oncologico Veneto - IRCCS
RECRUITING

Padua, 35128, Italy
Jolimont
RECRUITING

Haine Saint Paul La Louviere, 7100, Belgium
Kaohsiung Medical University Chung Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Karolinska Universitetssjukhuset
RECRUITING

Stockholm, 171 76, Sweden
Kindai University Hospital
RECRUITING

Sakai, 590 0197, Japan
Klinikum der Universitaet Muenchen
RECRUITING

Munich, 81377, Germany
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
Krankenhaus NorthWest
RECRUITING

Frankfurt am Main, 60488, Germany
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, 41404, South Korea
Liaoning Cancer Hospital and Institute
RECRUITING

Shenyang, 110042, China
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan District, 333, Taiwan
Los Angeles Cancer Network
RECRUITING

Glendale, California, 91204, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Mahamana Pandit Madan Mohan Malviya Cancer Centre
RECRUITING

Varanasi, 221005, India
Markhot Ferenc Oktatokorhaz es Rendelointezet
RECRUITING

Eger, 3300, Hungary
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
RECRUITING

Istanbul, 34899, Turkey (Türkiye)
Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States
Meander Medisch Centrum
RECRUITING

Amersfoort, 3813 TZ, Netherlands
MedStar Franklin Square Medical Center
RECRUITING

Baltimore, Maryland, 21237, United States
Medical College Of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Montefiore Einstein Comprehensive Cancer Center
RECRUITING

The Bronx, New York, 10461, United States
Mount Sinai Medical Center Campus
RECRUITING

Miami Beach, Florida, 33140, United States
Mount Vernon Cancer Centre
RECRUITING

Northwood, HA6 2RN, United Kingdom
NYU Langone Medical Center NYU Hematology Associates
RECRUITING

New York, New York, 10016, United States
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
RECRUITING

Warsaw, 02 034, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach
RECRUITING

Gliwice, 44 100, Poland
National Cancer Center Hospital
RECRUITING

Chūōku, 104 0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277 8577, Japan
National Center for Tumor Diseases NCT
RECRUITING

Heidelberg, 69120, Germany
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Osaka National Hospital
RECRUITING

Osaka, 540 0006, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10043, Taiwan
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi
RECRUITING

Konya, 42090, Turkey (Türkiye)
Neolife Medical Center Bucharest
RECRUITING

Bucharest, 077190, Romania
New York Cancer and Blood Specialists
RECRUITING

Shirley, New York, 11967, United States
Oncocenter
RECRUITING

Puebla City, 72530, Mexico
Oregon Health And Science University
RECRUITING

Portland, Oregon, 97239, United States
Osaka International Cancer Institute
RECRUITING

Osaka, 541 8567, Japan
Pan American Center for Oncology Trials LLC
RECRUITING

San Juan, 00935, Puerto Rico
Pecsi Tudomanyegyetem
COMPLETED

Pécs, 7624, Hungary
Peking University First Hospital
RECRUITING

Beijing, 100034, China
Pelican Impex SRL
RECRUITING

Oradea, 410469, Romania
Perlmutter Cancer Center at NYU Long Island
RECRUITING

Mineola, New York, 11501, United States
Piedmont Cancer Institute
RECRUITING

Atlanta, Georgia, 30318, United States
Ponderas Academic Hospital
RECRUITING

Bucharest, 014142, Romania
Prince Of Wales Hospital
RECRUITING

Shatin, Hong Kong
Providence Medical Foundation
RECRUITING

Santa Rosa, California, 95403, United States
Providence Regional Cancer System
RECRUITING

Lacey, Washington, 98503, United States
Queen Elizabeth Hospital
RECRUITING

South Woodville, 5011, Australia
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Radboud University Medical Center
RECRUITING

Nijmegen, 6525 GA, Netherlands
Rajiv Gandhi Cancer Institute and Research Centre
RECRUITING

Delhi, 110085, India
Ramathibodi Hospital
RECRUITING

Bangkok, 10400, Thailand
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Richmond VA Medical Center
RECRUITING

Richmond, Virginia, 23249, United States
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie
RECRUITING

Olsztyn, 10 228, Poland
SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego
RECRUITING

Opole, 45 061, Poland
Safdarjung Hospital
RECRUITING

New Delhi, 110029, India
Sahlgrenska Universitetssjukhuset
RECRUITING

Gothenburg, 413 45, Sweden
Sakarya University Training and Research Hospital
RECRUITING

Sakarya, 54290, Turkey (Türkiye)
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Scott And White Memorial Hospital
RECRUITING

Temple, Texas, 76508, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Shizuoka Cancer Center
RECRUITING

Shizuoka, 411 8777, Japan
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand
Skanes universitetssjukhus
RECRUITING

Lund, 222 42, Sweden
Sodersjukhuset
RECRUITING

Stockholm, 118 83, Sweden
Songklanagarind hospital
RECRUITING

Songkhla, 90110, Thailand
Spitalul Memorial Baneasa
RECRUITING

Bucharest, 013812, Romania
St Bartholomew's Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
St James University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
St. Bernard's Medical Center
RECRUITING

Jonesboro, Arkansas, 72401, United States
Sun Yat Sen University Cancer Center
RECRUITING

Guangzhou, 100142, China
Szegedi Tudomanyegyetem
RECRUITING

Szeged, 6720, Hungary
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza
RECRUITING

Brzozów, 36 200, Poland
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Tata Memorial Hospital
RECRUITING

Mumbai, 400012, India
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Tennessee Oncology
RECRUITING

Chattanooga, Tennessee, 37404, United States
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology DFW
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology West Texas
RECRUITING

Abilene, Texas, 79606, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Tokyo, 135 8550, Japan
The Catholic University of Korea Seoul St Mary s Hospital
RECRUITING

Seoul, 06591, South Korea
The First Affiliated Hospital of NanChang University
RECRUITING

Nanchang, 330006, China
The First Bethune Hospital of Jilin University
RECRUITING

Changchun, 130021, China
The Second Affiliated Hospital of Zhejiang University
RECRUITING

Hangzhou, 310009, China
The Sixth Affiliated Hospital Sun Yat sen University
RECRUITING

Guangzhou, 510655, China
The University of Osaka Hospital
RECRUITING

Suita, 565 0871, Japan
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, 300060, China
Torrance Memorial Physicians Network
RECRUITING

Torrance, California, 90505, United States
UCLA
RECRUITING

Santa Monica, California, 90404, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Health East Texas HOPE Cancer Center
RECRUITING

Tyler, Texas, 75701, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
Universitatsmedizin der Johannes Gutenberg Universitat Mainz
RECRUITING

Mainz, 55131, Germany
University Cancer And Blood Center LLC
RECRUITING

Athens, Georgia, 30607, United States
University College Hospital
RECRUITING

London, NW1 2BU, United Kingdom
University Hospital of Cleveland
RECRUITING

Cleveland, Ohio, 44106, United States
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232 1301, United States
University of Colorado Denver Anschultz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 214, Poland
Uppsala University
RECRUITING

Uppsala, SE 751 85, Sweden
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Cancer Specialists
RECRUITING

Arlington, Virginia, 22201, United States
Warringal Private Hospital
RECRUITING

Heidelberg, 3084, Australia
Washington University School Of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West China Hospital of Sichuan University
RECRUITING

Chengdu, 610041, China
Western Health Sunshine Hospital
RECRUITING

St Albans, 3021, Australia
Winship Cancer Institute Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Wojewodzki Szpital Specjalistyczny
RECRUITING

Biała Podlaska, 21 500, Poland
Yitzhak Shamir Medical Center
RECRUITING

Beer Yaakov, 70300, Israel
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, 310022, China

Conditions

Explore the condition pages connected to this study.

COLORECTAL NEOPLASMS