New hope for Tough-to-Treat rare diseases: experimental drug targets faulty cell signals
NCT ID NCT04079179
Summary
This study is testing whether the drug cobimetinib can help control several rare disorders caused by overactive immune cells, particularly when standard treatments have failed. The trial will enroll 90 children and adults with conditions like Langerhans cell histiocytosis (LCH) and related disorders. Cobimetinib works by blocking a specific protein (MEK) that sends incorrect growth signals in these diseases.
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Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Orange County
RECRUITINGOrange, California, 92868, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Medical Center- UTSW
RECRUITINGDallas, Texas, 75235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana Farber Cancer Institute, Boston Children's
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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John Hopkins University School of Medicine
RECRUITINGBaltimore, Maryland, 21287, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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NACHO Consortium
NOT_YET_RECRUITINGMemphis, Tennessee, 38105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCSF Benioff Children's Hospital
RECRUITINGSan Francisco, California, 94158, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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University of Wisconsin-American Family Children's Hospital
TERMINATEDMadison, Wisconsin, 53792, United States
Conditions
Explore the condition pages connected to this study.