New triplet therapy aims to control leukemia without lifelong treatment

NCT ID NCT05536349

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 23 times

Summary

This study tests a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—in people with chronic lymphocytic leukemia (CLL) or Richter transformation (RT) who haven't had treatment before. The goal is to see if this time-limited therapy is safe and effective at controlling the disease. About 60 adults will take part, and researchers will monitor side effects closely.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • M D Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.