Head-to-Head trial tests new hope for tough blood cancer

NCT ID NCT02477696

Ongoing Disease control Sponsor: Acerta Pharma BV Source: ClinicalTrials.gov ↗

Summary

This study compares two targeted drugs, acalabrutinib and ibrutinib, for adults with a hard-to-treat form of chronic lymphocytic leukemia (CLL) who have already had at least one prior therapy. The main goal is to see if acalabrutinib can keep the cancer from getting worse for as long as or longer than the standard drug, ibrutinib, while also checking for side effects like infections and heart rhythm issues. It is for people with specific high-risk genetic features in their cancer cells.

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Contacts and locations

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Locations

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Phoenix, Arizona, 85054, United States
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Anaheim, California, 92801, United States
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Berkeley, California, 94704, United States
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Duarte, California, 91010, United States
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La Jolla, California, 92093, United States
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Los Angeles, California, 90095, United States
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Palo Alto, California, 94304, United States
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Santa Rosa, California, 95403, United States
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Jacksonville, Florida, 32224, United States
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Tampa, Florida, 33612, United States
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Athens, Georgia, 30607, United States
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Harvey, Illinois, 60426, United States
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Peoria, Illinois, 61615, United States
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Wichita, Kansas, 67214, United States
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Minneapolis, Minnesota, 55426, United States
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Rochester, Minnesota, 55905, United States
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Billings, Montana, 59102, United States
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Hackensack, New Jersey, ?07601, United States
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Lake Success, New York, 11042, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10021, United States
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New York, New York, 10029, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27710, United States
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Columbus, Ohio, 43210, United States
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Philadelphia, Pennsylvania, 19104, United States
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Houston, Texas, 77030, United States
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Round Rock, Texas, 78665, United States
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Charlottesville, Virginia, 22908, United States
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Tacoma, Washington, 98405, United States
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Northwest WA, Wisconsin, 20007, United States
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Darlinghurst, 2010, Australia
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Frankston, 3199, Australia
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Melbourne, 3000, Australia
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St Leonards, 2065, Australia
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Waratah NSW, 2298, Australia
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Wollongong, 2500, Australia
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Bruges, 8000, Belgium
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Yvoir, 5530, Belgium
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Aalborg, 9100, Denmark
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Indgang 27B, DK-4000, Denmark
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Bobigny, 93000, France
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Créteil, 94010, France
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Pierre-Bénite, 69310, France
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Rennes, 35000, France
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Rouen, 76038, France
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Toulouse, 31059, France
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München, 81241, Germany
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Ulm, 89081, Germany
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Budapest, 1083, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Kaposvár, 7400, Hungary
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Haifa, 31000, Israel
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Haifa, 31096, Israel
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Haifa, 34362, Israel
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Jerusalem, 9103102, Israel
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Nahariya, 22100, Israel
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Petah Tikvah, 49102, Israel
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Tel Litwinsky, 52621, Israel
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Tiberias, 15208, Israel
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Bologna, 40138, Italy
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Cagliari, 9121, Italy
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Cona, 44124, Italy
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Florence, 50134, Italy
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Meldola, 47014, Italy
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Milan, 20162, Italy
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Milan, 20132, Italy
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Modena, 41100, Italy
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Ravenna, 48121, Italy
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Rome, 168, Italy
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Almere Stad, 1315 RA, Netherlands
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Amsterdam, 1105 AZ, Netherlands
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Blaricum, 1261, Netherlands
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Breda, 4818 CK, Netherlands
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Delft, 2600 GA, Netherlands
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Dordrecht, 3317, Netherlands
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Geleen, 6162 BG, Netherlands
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Groningen, 9700, Netherlands
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Haarlem, 2035 RC, Netherlands
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Leiden, 2333, Netherlands
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Rotterdam, 3062 PA, Netherlands
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Rotterdam, 3083 AN, Netherlands
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Utrecht, 3584, Netherlands
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Zutphens, 7207 AE, Netherlands
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Addington, 8011, New Zealand
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Auckland, ?0620, New Zealand
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Tauranga, 3112, New Zealand
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Bydgoszcz, 85-168, Poland
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Gdansk, 80-129, Poland
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Gdynia, 81-519, Poland
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Krakow, 30-727, Poland
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Lodz, 93-510, Poland
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Olsztyn, 10-228, Poland
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Opole, 46-020, Poland
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Słupsk, 76-200, Poland
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Wroclaw, 50-001, Poland
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Barcelona, 8907, Spain
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Barcelona, ?08041, Spain
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Madrid, 28006, Spain
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Madrid, 28009, Spain
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Madrid, 28031, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Murcia, 30008, Spain
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Santander, 39008, Spain
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Ankara, 6230, Turkey (Türkiye)
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Ankara, 6560, Turkey (Türkiye)
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Instabul, 34365, Turkey (Türkiye)
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Istanbul, 34452, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Izmir, 35340, Turkey (Türkiye)
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Kayseri, 38030, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Bournemouth, BH7 7DW, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Cardiff, CF14 4XW, United Kingdom
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Greater London, E1 2AD, United Kingdom
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Hull, HU32JZ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Leicester, LE1 7RH, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, SE5 9RS, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Southampton, SO16 6YD, United Kingdom
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Surrey, SM2 5PT, United Kingdom

Conditions

Explore the condition pages connected to this study.

CHRONIC LYMPHOCYTIC LEUKEMIA