New gel could soothe stubborn back itch
NCT ID NCT06262607
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a gel called CLE-400 for chronic itching in adults with notalgia paresthetica, a nerve-related condition that causes persistent itch on the back. Fifty-nine participants applied the gel or a placebo daily for four weeks. Researchers measured how much the worst itch improved using a 0-to-10 scale.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CLE-400 topical gel
What this could lead to
If it works, this could point toward a new treatment for chronic itching in people with notalgia paresthetica.
What could go wrong
This is an early Phase 2 study with only 59 participants, so results may not apply to everyone. The gel may not reduce itch better than a placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinical Site 02
Indianapolis, Indiana, 46250, United States
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Clinical Site 06
San Antonio, Texas, 78213, United States
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Clinical Site 09
Dublin, Ohio, 43016, United States
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Clinical Site 10
North Miami Beach, Florida, 33116, United States
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Clinical Site 13
Margate, Florida, 33063, United States
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Clinical Site 15
New York, New York, 10028, United States
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Clinical Site 20
Portsmouth, New Hampshire, 03801, United States
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Clinical Site 21
Fremont, California, 94538, United States
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Clinical Site 23
Methuen, Massachusetts, 01844, United States
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Clinical site 01
Coral Gables, Florida, 33134, United States
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Clinical site 03
High Point, North Carolina, 27262, United States
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Clinical site 11
Bryant, Arkansas, 72022, United States
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Clinical site 16
Houston, Texas, 77004, United States