New gel could soothe stubborn back itch
NCT ID NCT06262607
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a gel called CLE-400 for chronic itching in adults with notalgia paresthetica, a nerve-related condition that causes persistent itch on the back. Fifty-nine participants applied the gel or a placebo daily for four weeks. Researchers measured how much the worst itch improved using a 0-to-10 scale.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CLE-400 topical gel
- What this could lead to
- If it works, this could point toward a new treatment for chronic itching in people with notalgia paresthetica.
- What could go wrong
- This is an early Phase 2 study with only 59 participants, so results may not apply to everyone. The gel may not reduce itch better than a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Site 02
Indianapolis, Indiana, 46250, United States
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Clinical Site 06
San Antonio, Texas, 78213, United States
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Clinical Site 09
Dublin, Ohio, 43016, United States
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Clinical Site 10
North Miami Beach, Florida, 33116, United States
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Clinical Site 13
Margate, Florida, 33063, United States
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Clinical Site 15
New York, New York, 10028, United States
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Clinical Site 20
Portsmouth, New Hampshire, 03801, United States
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Clinical Site 21
Fremont, California, 94538, United States
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Clinical Site 23
Methuen, Massachusetts, 01844, United States
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Clinical site 01
Coral Gables, Florida, 33134, United States
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Clinical site 03
High Point, North Carolina, 27262, United States
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Clinical site 11
Bryant, Arkansas, 72022, United States
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Clinical site 16
Houston, Texas, 77004, United States