New depression pill shows promise in early trial

NCT ID NCT04103892

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 29 times

Summary

This study tested a new drug called CLE-100 in 146 adults with major depressive disorder who were already taking standard antidepressants. The goal was to see if adding CLE-100 could further reduce depression symptoms. Participants were randomly assigned to receive either CLE-100 or a placebo, and their depression severity was measured using a standard rating scale.

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Contacts and locations

Locations

  • Clinical Site 101

    Marlton, New Jersey, 08053, United States

  • Clinical Site 102

    Staten Island, New York, 10312, United States

  • Clinical Site 103

    Boston, Massachusetts, 02114, United States

  • Clinical Site 104

    Decatur, Georgia, 30030, United States

  • Clinical Site 105

    Orlando, Florida, 32803, United States

  • Clinical Site 106

    Media, Pennsylvania, 19063, United States

  • Clinical Site 107

    Hialeah, Florida, 33016, United States

  • Clinical Site 108

    Miami Gardens, Florida, 33014, United States

  • Clinical Site 109

    Houston, Texas, 77030, United States

  • Clinical Site 110

    Las Vegas, Nevada, 89102, United States

  • Clinical Site 111

    Hickory, North Carolina, 28601, United States

  • Clinical Site 112

    Torrance, California, 90502, United States

  • Clinical Site 113

    Oceanside, California, 92056, United States

  • Clinical Site 114

    Fort Worth, Texas, 76104, United States

  • Clinical Site 115

    Bellflower, California, 90706, United States

  • Clinical Site 116

    Miami, Florida, 33145, United States

  • Clinical Site 117

    Oakland, California, 94607, United States

  • Clinical Site 118

    Philadelphia, Pennsylvania, 19104, United States

  • Clinical Site 120

    Little Rock, Arkansas, 72209, United States

  • Clinical Site 121

    Boston, Massachusetts, 02131, United States

  • Clinical Site 122

    Marietta, Georgia, 30060, United States

  • Clinical Site 123

    Riverside, California, 92506, United States

  • Clinical Site 124

    Santa Ana, California, 92705, United States

  • Clinical Site 125

    Lincoln, Nebraska, 68526, United States

  • Clinical Site 126

    Bentonville, Arkansas, 72712, United States

  • Clinical Site 127

    North Canton, Ohio, 44720, United States

  • Clinical Site 128

    New York, New York, 10036, United States

  • Clinical Site 129

    Little Rock, Arkansas, 72209, United States

  • Clinical Site 131

    Baltimore, Maryland, 21208, United States

  • Clinical Site 132

    Lafayette, California, 94549, United States

  • Clinical Site 135

    Bellevue, Washington, 98007, United States

  • Clinical Site 136

    Rockville, Maryland, 20877, United States

  • Clinical Site 137

    Orlando, Florida, 32807, United States

  • Clinical Site 138

    Middleburg Heights, Ohio, 44130, United States

  • Clinical Site 139

    St Louis, Missouri, 63128, United States

  • Clinical Site 140

    Atlanta, Georgia, 30338, United States

  • Clinical Site 141

    Anaheim, California, 92805, United States

  • Clinical Site 142

    Santa Rosa, California, 95401, United States

  • Clinical Site 143

    Raleigh, North Carolina, 27609, United States

  • Clinical Site 144

    Plano, Texas, 75093, United States

  • Clinical Site 145

    Denver, Colorado, 80209, United States

  • Clinical Site 147

    Draper, Utah, 84020, United States

  • Clinical Site 148

    Toms River, New Jersey, 08755, United States

  • Clinical Site 149

    Missouri City, Texas, 88459, United States

  • Clinical Site 150

    San Juan, 00918, Puerto Rico

  • Clinical Site 151

    Dearborn Heights, Michigan, 48034, United States

Conditions

Explore the condition pages connected to this study.