New oral esketamine pill shows promise for stubborn depression

NCT ID NCT06340958

Completed Symptom relief Sponsor: Clexio Biosciences Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called CLE-100 (oral esketamine) in 99 adults with major depression that didn't get better after trying at least two standard antidepressants. Participants took CLE-100 or a placebo pill alongside their usual antidepressant for several weeks. The goal was to see if adding CLE-100 could further reduce depression symptoms, measured by a standard rating scale.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Locations

Clinical Site 101

Toms River, New Jersey, 08755, United States
Clinical Site 102

Hollywood, Florida, 33024, United States
Clinical Site 103

Beachwood, Ohio, 44236, United States
Clinical Site 105

Lauderhill, Florida, 33319, United States
Clinical Site 107

Austin, Texas, 78737, United States
Clinical Site 108

Gaithersburg, Maryland, 20877, United States
Clinical Site 114

Savannah, Georgia, 31405, United States
Clinical Site 115

Bellevue, Washington, 98007, United States
Clinical Site 116

Flowood, Mississippi, 39232, United States
Clinical Site 117

Murray, Utah, 84107, United States
Clinical Site 118

Atlanta, Georgia, 30030, United States
Clinical Site 119

North Canton, Ohio, 44720, United States
Clinical Site 120

Elgin, Illinois, 60123, United States
Clinical Site 126

O'Fallon, Missouri, 63368, United States
Clinical Site 127

Chicago, Illinois, 60640, United States
Clinical Site 130

Upland, California, 91786, United States
Clinical Site 131

Lafayette, California, 94549, United States
Clinical Site 132

Pensacola, Florida, 32502, United States
Clinical Site 135

Oklahoma City, Oklahoma, 73112, United States
Clinical Site 137

Plano, Texas, 75093, United States
Clinical Site 138

Marietta, Georgia, 30060, United States
Clinical Site 139

La Jolla, California, 92037, United States
Clinical Site 140

Miami Springs, Florida, 33166, United States