New heart pill aims to ease thick heart muscle symptoms

NCT ID NCT04219826

Completed Disease control Sponsor: Cytokinetics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new daily pill called CK-3773274 (aficamten) in 96 adults with symptomatic hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. The goal was to find the right dose and check safety, including effects on heart pumping strength. Participants took either the drug or a placebo for 10 weeks, and researchers monitored side effects and heart function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CK-3773274 (aficamten) tablets taken by mouth once daily
What this could lead to: If it works, this could lead to a new daily pill to control symptoms and improve heart function in people with hypertrophic cardiomyopathy.
What could go wrong: This is a small, early-phase trial focused on safety and dosing, not proof of effectiveness. The drug may not work better than placebo or could cause side effects like reduced heart pumping function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertrophic cardiomyopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTROPHIC CARDIOMYOPATHY (HCM)

Contacts and locations

Locations

Azienda Ospedaliero Universitaria Careggi

Florence, Italy
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Carolinas Medical Center

Charlotte, North Carolina, 28203, United States
Cedar-Sinai Medical Center

Los Angeles, California, 90048, United States
Complejo Hospitalario Universitario A Coruña

A Coruña, 15003, Spain
Duke Cardiology at Southpoint

Durham, North Carolina, 27713, United States
Erasmus University Medical Center (Erasmus MC)

Rotterdam, Netherlands
Hospital Universitario Puerta de Hierro de Majadahonda

Madrid, Spain
Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine)

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Michigan Medicine - University of Michigan

Ann Arbor, Michigan, 48109, United States
New York University Langone Health Medical Center

New York, New York, 10016, United States
Northwestern University

Evanston, Illinois, 60208, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UCSF Medical Center

San Francisco, California, 94143, United States
UMPC Heart and Vascular Institute

Pittsburgh, Pennsylvania, 15213, United States
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Virginia Health System

Charlottesville, Virginia, 22903, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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