Can a new anesthetic shield the brain during tumor surgery?
NCT ID NCT07805876
First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time
Summary
This trial compares two anesthetics, ciprofol and propofol, given during surgery to remove brain tumors that raise pressure inside the skull. The goal is to see whether ciprofol reduces common post-surgery problems like confusion (delirium) and stroke. About 434 adults scheduled for such surgery will be randomly assigned to receive one of the two drugs. Researchers will track how many patients develop these complications in the days after the operation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ciprofol, an experimental intravenous anesthetic, compared with the standard anesthetic propofol
- What this could lead to
- If ciprofol works better, it could lower the risk of confusion and stroke after brain tumor surgery, helping patients recover more smoothly.
- What could go wrong
- This is an early test, and ciprofol may not prove better than propofol. Anesthesia drugs can also cause side effects like low blood pressure or allergic reactions.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 434 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * American Society of Anesthesiologists physical status I to III * Patients scheduled for elective surgery for supratentorial intracranial tumors, with imaging findings meeting the following criteria: 1. Displacement of midline structures (e.g., septum pellucidum, pineal gland, falx cerebri) by ≥5 mm due to the tumor's mass effect or peritumoral edema; 2. . Compression or deformation of the ventricular system, particularly symmetric or asymmetric narrowing of the lateral ventricles and the third ventricle; 3. . Shallowed or absent sulci, fissures, and cisterns, with the subarachnoid spaces compressed due to brain tissue swelling or mass effect * Obtain written informed consent Exclusion Criteria: * History of transient ischemic attack or cerebral infarction within the past one year * Patients with a history of psychiatric or neurological disorders (such as depression, schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis) or those taking antipsychotic medications, antidepressants, glucocorticoids, as well as patients with alcohol abuse or illicit drug abuse * Personal history of intellectual disability or a preoperative Mini-Mental State Examination score indicating impaired cognitive function (defined as follows based on the subject's educational level: illiterate \< 17 points, elementary school education \< 20 points, middle school education or higher \< 24 points), language disorders, or inability to cooperate with the researcher during psychiatric assessment * Uncontrolled hypertension, diabetes, or a history of hematological disorders * Preoperative severe hepatic or renal insufficiency * Contraindications to the use of cyclopropane and propofol
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Beijing Tian Tan Hospital, Capital Medical University
Beijing, Beijing Municipality, 100070, China
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