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Can a bout of exercise change chronic cough?

NCT ID NCT06766175

Knowledge-focused Sponsor: University of Leeds Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This study looks at how refractory chronic cough—a persistent cough lasting over 8 weeks—affects people's ability to do everyday activities. Researchers will compare daily step counts and cough frequency in 60 adults with chronic cough against healthy controls. They will also test whether a single session of high-intensity exercise alters cough frequency or severity in the following 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-intensity exercise challenge
What this could lead to
If this trial succeeds, it could reveal whether exercise is safe and beneficial for people with chronic cough, potentially guiding lifestyle advice and rehabilitation programs.
What could go wrong
This is an observational and interventional study with a small sample size. Results may not apply to all chronic cough patients, and exercise could temporarily worsen cough in some individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Dec 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with refractory chronic cough will be recruited from the Hull Cough Clinic, Castle Hill Hospital.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>18 years * Chronic cough as per European Respiratory Society definition (\>8 weeks duration) * High symptom burden (i.e., cough visual analogue scale \>40 mm at pre-study screening) * Chest radiograph or CT within 3 years of the screening visit with no abnormalities considered to contribute to chronic cough Exclusion Criteria: * Smokers or individuals who gave up smoking within 12 months * Smoking history \>20 pack-years * Long-COVID or post-COVID syndrome (defined as symptoms lasting over 12-weeks in duration) * Recent exacerbation of cough within 4 weeks of inclusion * Respiratory tract infection within 4 weeks of inclusion * Currently taking any of the following medications: * ACE inhibitors and within 3 months of inclusion * Antitussives (opioids, pregabalin, gabapentin, amitriptyline, nortriptyline, or over the-counter medications) within 2 weeks of inclusion * Medical treatments for gastro-oesophageal reflux disease (GORD), eosinophilic bronchitis or other cough related conditions, initiated or changed (i.e., not in a stable regimen) for 4 weeks prior to inclusion * Medical history of asthma or exercise-induced bronchoconstriction (EIB), COPD, or chronic bronchitis in the judgement of the investigator * Medical conditions/history or other circumstances which, in the judgement of the investigators, could increase the risk of adverse events or bias the study results

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Conditions

The condition(s) this trial relates to.

Chronic Cough Cough Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic cough (CC) Healthy adult participants

Contacts and locations

Locations

  • University of Leeds

    Leeds, West Yorkshire, LS2 9JT, United Kingdom

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