Can At-Home malaria pills work as well as supervised care?

NCT ID NCT07753967

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial compares two ways of taking the standard malaria treatment for Plasmodium vivax: one group receives chloroquine and primaquine under direct medical supervision, while the other takes the same medication at home with phone check-ins. The goal is to see if unsupervised treatment is as effective at clearing the parasite and preventing relapse. About 192 patients with uncomplicated vivax malaria in southwest Ethiopia are taking part. The study tracks cure rates, parasite clearance, and how well patients stick to the 14-day regimen.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Chloroquine and Primaquine combination therapy
What this could lead to
If effective, this could confirm that standard chloroquine-primaquine treatment works against P. vivax malaria in Ethiopia, even when taken at home without supervision.
What could go wrong
The trial is relatively small and observational in nature, and unsupervised adherence may be poor, potentially reducing effectiveness. Results may not apply to other regions.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Jimma Health Center

    Jimma, Oromiya, 1000, Ethiopia

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