Which antiseptic wins? study tests chlorhexidine vs Povidone-Iodine for thoracoscopy infections
NCT ID NCT05430308
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether cleaning the skin with chlorhexidine-alcohol before a lung procedure (medical thoracoscopy) prevents infections better than the standard povidone-iodine. One hundred patients with undiagnosed fluid around the lung were randomly assigned to one of the two antiseptics. The main goal was to see which one leads to fewer wound or chest infections after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Chlorhexidine scrub and povidone-iodine solution
- What this could lead to
- If chlorhexidine works better, it could reduce infections after thoracoscopy, making the procedure safer for patients with undiagnosed pleural effusion.
- What could go wrong
- This is a small, single-center study with only 100 participants, so results may not apply broadly. Both antiseptics are already in use, so no major breakthrough is expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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100 people
The number who actually took part.
- Started
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Apr 2022
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 80 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥12 \<80 years 2. Medical thoracoscopy being performed for the workup of undiagnosed pleural effusion Exclusion Criteria: 1. Patients with intercostal tube before MT 2. MT performed for adhesiolysis 3. Age \<12 or ≥80 years 4. SPO2 \<92% at room air 5. Hemodynamic instability 6. Myocardial infarction or unstable angina in the last 3 months 7. Hemoglobin \<8g/dl; Platelet count \<50,000 cell/dl 8. Lack of pleural space due to adhesions 9. Uncorrected coagulopathy (PT \> 3 seconds above control; APTT\> 10 seconds above control) 10. Failure to provide informed consent 11. Patients already taking any antibiotic due to any reason
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Bronchoscopy suite
Chandigarh, Chandigarh, 160012, India
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Bronchoscopy suite, PGIMER
Chandigarh, 160012, India
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