New combo therapy aims to shrink Hard-to-Treat lung tumors before surgery

NCT ID NCT05684276

Ongoing Disease control Sponsor: Fundación GECP Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests giving chemotherapy (carboplatin and paclitaxel) plus the immunotherapy drug nivolumab before surgery for people with Pancoast tumors, a rare type of lung cancer. After surgery, additional treatment is tailored based on whether the tumor was fully removed. The study aims to see if this approach helps more patients achieve complete tumor removal and improves survival. About 22 patients are enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin, Paclitaxel, and Nivolumab
What this could lead to: If successful, this approach could improve the chances of complete tumor removal and extend survival for people with this rare lung cancer.
What could go wrong: This is a small, early-phase trial with only 22 participants, so results may not apply broadly. Chemo and immunotherapy can cause serious side effects.

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Conditions

The condition(s) this trial relates to.

lung superior sulcus carcinoma malignant superior sulcus neoplasm non-small cell lung carcinoma Pancoast syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NSCLC PANCOAST TUMOR

Contacts and locations

Locations

Complexo Hospitalario Universitario De Vigo

Vigo, Vigo, 36204, Spain
Consorci Sanitari de Terrassa

Terrassa, Terrassa, 08227, Spain
Fundació Althaïa

Manresa, Manresa, 08243, Spain
Hospital 12 De Octubre

Madrid, Madrid, 28041, Spain
Hospital Clínic De Barcelona

Barcelona, Barcelona, 08036, Spain
Hospital Clínico San Carlos

Madrid, Madrid, 28040, Spain
Hospital Clínico Universitario de Valladolid

Valladolid, Valladolid, 47003, Spain
Hospital Clínico de Valencia

Valencia, Valencia, 46010, Spain
Hospital De Mataro

Mataró, Barcelona, 08304, Spain
Hospital General Universitario de Elche

Alicante, Alicante, 03203, Spain
Hospital General Universitario de Valencia

Valencia, Valencia, 46014, Spain
Hospital Josep Trueta

Girona, Girona, 17007, Spain
Hospital Parc Taulí

Barcelona, Barcelona, 08208, Spain
Hospital San Pedro De Alcántara

Cáceres, Cáceres, 10003, Spain
Hospital Son Espases

Palma de Mallorca, Palma de Mallorca, 07120, Spain
Hospital Universitari Quiron Dexeus

Barcelona, Barcelona, 08028, Spain
Hospital Universitari Vall d' Hebron

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Dr. Peset

Valencia, Valencia, 46017, Spain
Hospital Universitario Fundación Jiménez Díaz

Madrid, Madrid, 28040, Spain
Hospital Universitario Jerez De La Frontera

Jerez de la Frontera, Cádiz, 11407, Spain
Hospital Universitario La Fe

Valencia, Valencia, 46026, Spain
Hospital Universitario Lucus Augusti

Lugo, Lugo, 27003, Spain
Hospital Universitario Puerta de Hierro

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Regional de Málaga

Málaga, Málaga, 29010, Spain
Hospital Universitario Salamanca

Salamanca, Salamanca, 37007, Spain
Hospital Universitario Virgen Del Rocio

Seville, Sevilla, 41013, Spain
Hospital Universitario de Cruces

Bilbao, Bilbao, 48903, Spain
Hospital Universitario de Jaén

Jaén, Jaén, 23007, Spain
Hospital Universitario la Paz

Madrid, Madrid, 28046, Spain

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