New trial tests aggressive combo therapy to fight tough cervical cancers

NCT ID NCT07061977

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is for people with cervical cancer that has spread to nearby tissues or lymph nodes. It compares two treatment plans that combine chemotherapy, radiation, and an immunotherapy drug called pembrolizumab. One plan adds extra chemotherapy and immunotherapy at the start. The goal is to see which approach is better at keeping the cancer from growing or coming back.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

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Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005-1066, United States

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Aultman Health Foundation
RECRUITING

Canton, Ohio, 44710, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States

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Broward Health Medical Center
RECRUITING

Fort Lauderdale, Florida, 33316, United States

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CTCA at Southeastern Regional Medical Center
RECRUITING

Newnan, Georgia, 30265, United States

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Camden Clark Medical Center
RECRUITING

Parkersburg, West Virginia, 26101, United States

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Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States

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Capital Health Medical Center-Hopewell
RECRUITING

Pennington, New Jersey, 08534, United States

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Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

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Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

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Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

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Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

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Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

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City of Hope Antelope Valley
SUSPENDED

Lancaster, California, 93534, United States
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

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City of Hope Corona
RECRUITING

Corona, California, 92882, United States

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City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States

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City of Hope Upland
RECRUITING

Upland, California, 91786, United States

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City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States

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Clackamas Radiation Oncology Center
RECRUITING

Clackamas, Oregon, 97015, United States

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Community Medical Center
SUSPENDED

Missoula, Montana, 59804, United States
Crossroads Cancer Center
SUSPENDED

Effingham, Illinois, 62401, United States
Danbury Hospital
RECRUITING

Danbury, Connecticut, 06810, United States

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Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States

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Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States

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Duke Women's Cancer Care Raleigh
RECRUITING

Raleigh, North Carolina, 27607, United States

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East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States

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Farmington Health Center
RECRUITING

Farmington, Utah, 84025, United States

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Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States

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Geauga Hospital
RECRUITING

Chardon, Ohio, 44024, United States

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Gibbs Cancer Center-Gaffney
RECRUITING

Gaffney, South Carolina, 29341, United States

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Gibbs Cancer Center-Pelham
RECRUITING

Greer, South Carolina, 29651, United States

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Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States

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Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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IRMC Cancer Center
RECRUITING

Indiana, Pennsylvania, 15701, United States

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Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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Jersey City Medical Center
RECRUITING

Jersey City, New Jersey, 07302, United States

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Kaiser Permanente Northwest
RECRUITING

Portland, Oregon, 97227, United States

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Kootenai Clinic Cancer Services - Post Falls
SUSPENDED

Post Falls, Idaho, 83854, United States
Kootenai Health - Coeur d'Alene
SUSPENDED

Coeur d'Alene, Idaho, 83814, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic
RECRUITING

Metairie, Louisiana, 70006, United States

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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

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Legacy Good Samaritan Hospital and Medical Center
RECRUITING

Portland, Oregon, 97210, United States

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Legacy Meridian Park Hospital
RECRUITING

Tualatin, Oregon, 97062, United States

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Legacy Salmon Creek Hospital
RECRUITING

Vancouver, Washington, 98686, United States

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Lehigh Valley Hospital - Muhlenberg
RECRUITING

Bethlehem, Pennsylvania, 18017, United States

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Lehigh Valley Hospital-Cedar Crest
RECRUITING

Allentown, Pennsylvania, 18103, United States

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Lenox Hill Hospital
RECRUITING

New York, New York, 10075, United States

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Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States

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MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States

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MaineHealth Coastal Cancer Treatment Center
RECRUITING

Bath, Maine, 04530, United States

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MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

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MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

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Manhattan Eye Ear and Throat Hospital
RECRUITING

New York, New York, 10065, United States

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Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States

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Memorial Hospital West
RECRUITING

Pembroke Pines, Florida, 33028, United States

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Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITING

Hollywood, Florida, 33021, United States

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Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States

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Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States

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Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States

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Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

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Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States

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Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States

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Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States

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Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States

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Miami Valley Hospital
RECRUITING

Dayton, Ohio, 45409, United States

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Miami Valley Hospital North
RECRUITING

Dayton, Ohio, 45415, United States

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Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

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Midwestern Regional Medical Center
RECRUITING

Zion, Illinois, 60099, United States

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Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States

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Montefiore Medical Center-Weiler Hospital
RECRUITING

The Bronx, New York, 10461, United States

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Mount Sinai Chelsea
RECRUITING

New York, New York, 10011, United States

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Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States

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Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States

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Northwell Health Cancer Institute at Huntington
RECRUITING

Greenlawn, New York, 11740, United States

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Northwell Health Imbert Cancer Center
RECRUITING

Bay Shore, New York, 11706, United States

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Northwell Health Physician Partners at Flushing
RECRUITING

Flushing, New York, 11354, United States

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Northwell Health Physicians Partners Radiation Medicine at Queens
RECRUITING

Forest Hills, New York, 11375, United States

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Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States

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Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States

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Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States

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Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States

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Northwestern Medicine Oak Brook
RECRUITING

Oak Brook, Illinois, 60523, United States

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Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

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Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

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Norwalk Hospital
RECRUITING

Norwalk, Connecticut, 06856, United States

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Ochsner Baptist Medical Center
RECRUITING

New Orleans, Louisiana, 70115, United States

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Ochsner Medical Center Jefferson
RECRUITING

New Orleans, Louisiana, 70121, United States

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Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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Oklahoma Cancer Specialists and Research Institute-Tulsa
RECRUITING

Tulsa, Oklahoma, 74146, United States

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Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

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Orlando Health Cancer Institute
RECRUITING

Orlando, Florida, 32806, United States

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Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

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Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States

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Piedmont Hospital
RECRUITING

Atlanta, Georgia, 30309, United States

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Pocono Medical Center
RECRUITING

East Stroudsburg, Pennsylvania, 18301, United States

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ProHealth D N Greenwald Center
RECRUITING

Mukwonago, Wisconsin, 53149, United States

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ProHealth Oconomowoc Memorial Hospital
RECRUITING

Oconomowoc, Wisconsin, 53066, United States

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ProMedica Flower Hospital
RECRUITING

Sylvania, Ohio, 43560, United States

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Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

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Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

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Queens Cancer Center
RECRUITING

Rego Park, New York, 11374, United States

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Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

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Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

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Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States

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Rutgers New Jersey Medical School
RECRUITING

Newark, New Jersey, 07101, United States

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Saint Luke's Cancer Center - Allentown
RECRUITING

Allentown, Pennsylvania, 18104, United States

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Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States

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Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States

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Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States

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Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States

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Saint Luke's Hospital - Monroe Campus
RECRUITING

Stroudsburg, Pennsylvania, 18360, United States

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Saint Luke's Hospital - Upper Bucks Campus
RECRUITING

Quakertown, Pennsylvania, 18951, United States

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Saint Luke's Hospital-Anderson Campus
RECRUITING

Easton, Pennsylvania, 18045, United States

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Saint Luke's University Hospital-Bethlehem Campus
RECRUITING

Bethlehem, Pennsylvania, 18015, United States

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Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States

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Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States

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Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States

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State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States

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Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States

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Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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Trinity Health Saint Joseph Mercy Oakland Hospital
SUSPENDED

Pontiac, Michigan, 48341, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

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UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

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UCHealth Highlands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129, United States

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UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States

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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

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UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITING

Mentor, Ohio, 44060, United States

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UH Seidman Cancer Center at Saint John Medical Center
RECRUITING

Westlake, Ohio, 44145, United States

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UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States

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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States

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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States

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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States

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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States

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UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States

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UM Sylvester Comprehensive Cancer Center at Coral Springs
RECRUITING

Coral Springs, Florida, 33065, United States

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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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UM Sylvester Comprehensive Cancer Center at Doral
RECRUITING

Doral, Florida, 33166, United States

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UM Sylvester Comprehensive Cancer Center at Hollywood
RECRUITING

Hollywood, Florida, 33021, United States

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UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States

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UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States

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UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States

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UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

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UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States

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UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States

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UPMC-Magee Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States

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UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States

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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

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UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

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UW Cancer Center at ProHealth Care
RECRUITING

Waukesha, Wisconsin, 53188, United States

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UW Health Carbone Cancer Center Rockford
RECRUITING

Rockford, Illinois, 61114, United States

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University Hospitals Parma Medical Center
RECRUITING

Parma, Ohio, 44129, United States

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University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States

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University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States

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University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States

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University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

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University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

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University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States

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University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States

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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
RECRUITING

North Miami, Florida, 33181, United States

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University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

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University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Utah Sugarhouse Health Center
RECRUITING

Salt Lake City, Utah, 84106, United States

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University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

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Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

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Upstate Cancer Center Radiation Oncology at Oswego
RECRUITING

Oswego, New York, 13126, United States

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Upstate Cancer Center at Hill Radiation Oncology
RECRUITING

Syracuse, New York, 13210, United States

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Upstate Cancer Center at Verona
RECRUITING

Verona, New York, 13478, United States

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VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

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West Jefferson Medical Center
RECRUITING

Marrero, Louisiana, 70072, United States

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West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States

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West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

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Women and Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States

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Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED CERVICAL ADENOCARCINOMA LOCALLY ADVANCED CERVICAL ADENOSQUAMOUS CARCINOMA LOCALLY ADVANCED CERVICAL SQUAMOUS CELL CARCINOMA STAGE IIIA CERVICAL CANCER FIGO 2018 STAGE IIIB CERVICAL CANCER FIGO 2018 STAGE IIIC1 CERVICAL CANCER FIGO 2018 STAGE IIIC2 CERVICAL CANCER FIGO 2018 STAGE IVA CERVICAL CANCER FIGO 2018