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Shoulder pain study: brain sensitivity may predict injection success

NCT ID NCT05926895

Knowledge-focused Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at 44 people with shoulder pain from rotator cuff tears to see if a condition called central sensitization (where the nervous system is extra sensitive to pain) changes how well a steroid injection works. Participants got a shot of betamethasone and prilocaine into the shoulder, and researchers measured pain and movement. The goal was to find out if those with central sensitization respond differently, which could help tailor treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Betamethasone and prilocaine injection
What this could lead to
If it works, this could help doctors predict which patients will benefit from steroid injections for shoulder pain, leading to more personalized treatment.
What could go wrong
This is a small, completed study (44 people) that only looks for a link, not a treatment. Results may not apply to everyone with shoulder pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Jun 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Rotator cuff pathology confirmed clinically and radiologically (USG/MRI) * Failure to respond to medical/physical treatment * Agree to participate in the study Exclusion Criteria: * Shoulder trauma and history of previous shoulder surgery * History of injection to the painful shoulder in the last 3 months * Use of centrally acting drugs (antidepressants, pregabalin, gabapentin and myorelaxant etc.) * History of active cancer, systemic inflammatory disease, and infection * Pregnancy

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Conditions

The condition(s) this trial relates to.

rotator cuff syndrome shoulder impingement syndrome Shoulder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Central sensitisation Subacromial impingement syndrome

Contacts and locations

Locations

  • Sultan Abdülhamid Han Research and Training Hospital

    Istanbul, Turkey (Türkiye)

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