Lung cancer vaccine combo shows promise in early trial
NCT ID NCT05557591
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether adding an mRNA vaccine (BNT116) to standard immunotherapy (cemiplimab) works better than immunotherapy alone for people with advanced non-small cell lung cancer. About 51 patients whose tumors have high PD-L1 levels will receive either the combination or just cemiplimab. The study aims to see if the vaccine helps shrink tumors and improve response rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cemiplimab (an immunotherapy drug) and BNT116 (an mRNA vaccine)
- What this could lead to
- If it works, this combination could shrink tumors or slow cancer growth better than immunotherapy alone, offering a new treatment option for advanced lung cancer.
- What could go wrong
- This is a small, early-phase trial (51 people) with no results yet. The vaccine may not boost effectiveness, and side effects from the combination could be worse than with immunotherapy alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Adana Medical Park Seyhan Hospital
Adana, Adana, 01140, Turkey (Türkiye)
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Althaia Xarxa Assistencial Universitaria Manresa
Manresa, Barcelona, 08243, Spain
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Asan Medical Center
Seoul, 05505, South Korea
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Baskent University
Yüreğir, Adana, 01230, Turkey (Türkiye)
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Bezmialem Foundation University Medical Faculty
Istanbul, 34093, Turkey (Türkiye)
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Catalan Institute of Oncology Badalona
Badalona, Barcelona, 08916, Spain
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Caucasus Medical Centre
Tbilisi, 0186, Georgia
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Chonnam National University Hwasun Hospital
Hwasun, Jeollanam-do, 58128, South Korea
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Clinica Universidad de Navarra
Pamplona, 31008, Spain
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Clinica Universidad de Navarra - Madrid
Madrid, 28027, Spain
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Consorcio Hospitalario Provincial de Castellon
Castellon, Castellon, 12002, Spain
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Ege University Faculty of Medicine
Bornova, İzmir, 35100, Turkey (Türkiye)
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FirstHealth of the Carolinas Outpatient Cancer Center
Pinehurst, North Carolina, 28374, United States
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Hospital General Universitario Gregorio Marañon (HGUGM)
Madrid, 28007, Spain
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Hospital Regional Universitario de Malaga
Málaga, 29010, Spain
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Virgen del Rocio
Málaga, 29010, Spain
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Instituto Valenciano de Oncologia
Valencia, 46009, Spain
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Istanbul Medeniyet University - Prof Dr Suleyman Yalcin Sehir Hospital
Istanbul, 81450, Turkey (Türkiye)
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Izmir Economy University Medical Point Hospital
Izmir, 35325, Turkey (Türkiye)
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Kaohsiung Medical University - Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Klinikum der Johann Wolfgang Goethe-Universitaet Frankfurt
Frankfurt, 60590, Germany
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Klinikverbund Kempten-Oberallgäu
Kempten, 87349, Germany
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Korea University Anam Hospital
Seoul, Gyeonggi-do, 02841, South Korea
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Krankenhaus Martha-Maria Halle-Doelau gGmbH
Halle, 06120, Germany
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LLC Todua Clinic
Tbilisi, 0112, Georgia
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LTD Cancer Research Centre
Tbilisi, 0179, Georgia
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LTD High Technology Hospital Medcenter
Batumi, 6000, Georgia
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LTD New Hospitals
Tbilisi, 0114, Georgia
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LTD Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic
Tbilisi, 0144, Georgia
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Millenium Research & Clinical Development
Houston, Texas, 77090, United States
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National Cancer Center Korea
Goyang, 10408, South Korea
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National Taiwan University Hospital
Taipei, 100225, Taiwan
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Northwest Medical Specialties, PLLC
Tacoma, Washington, 98405, United States
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Norton Cancer Institute, Downtown
Louisville, Kentucky, 40202, United States
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Ozel Liv Hospital
Ankara, 06100, Turkey (Türkiye)
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Samsung Medical Center
Seoul, 6351, South Korea
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San Juan Oncology Associates
Farmington, New Mexico, 87401, United States
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Sbu Doctor Abdurrahman Yurtaslan Ankara Onkoloji Suam
Ankara, 06100, Turkey (Türkiye)
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Seoul National University Hospital
Seoul, 744, South Korea
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Staedtisches Klinikum Muenchen Bogenhausen
München, Bavaria, 81925, Germany
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Taipei Medical University - Shuang Ho Hospital
New Taipei City, 23561, Taiwan
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Taipei Tzu Chi Hospital
New Taipei City, 23142, Taiwan
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The Oncology Institute of Hope and Innovation
Los Angeles, California, 90033, United States
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Tri-Service General Hospital
Taipei, 114, Taiwan
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UCLA Medical Center
Santa Monica, California, 90095, United States
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Universitaetsklinikum Giessen Und Marburg Gmbh Standort Giessen
Giessen, 80336, Germany
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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Weill Cornell Medicine
New York, New York, 10065, United States
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Yeditepe University Kosuyolu Hospital
Kadıköy, Istanbul, 34718, Turkey (Türkiye)
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Yonsei Severance
Seoul, 3722, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a pill outperform chemo for a Hard-to-Treat lung cancer mutation?
- Can a Triple-Drug combo outsmart Immunotherapy-Resistant lung cancer?
- Which palliative care approach boosts quality of life in advanced lung cancer?
- Experimental drug combo targets Hard-to-Treat lung cancer
- Can a smartphone app ease the burden of advanced lung cancer?
- Breath of discovery: simple test may sniff out lung cancer