New hope for Tough-to-Treat lung cancer? trial tests adding a Tumor-Starving drug

NCT ID NCT01064648

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study tested if adding a new drug called cediranib to standard chemotherapy (cisplatin and pemetrexed) works better for people with malignant pleural mesothelioma, a serious cancer often linked to asbestos. The trial had two parts: first to find a safe dose of cediranib, then to compare how long patients lived without their cancer getting worse when taking the new combo versus standard chemo with a placebo. The goal was to see if cediranib, which may block blood flow to tumors, helps the chemotherapy work better.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Allegiance Health

Jackson, Michigan, 49201, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States
Ballad Health Cancer Care - Kingsport

Kingsport, Tennessee, 37660, United States
Ballad Health Cancer Care - Norton

Norton, Virginia, 24273, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Big Horn Basin Cancer Center

Cody, Wyoming, 82414, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bristol Regional Medical Center

Bristol, Tennessee, 37620, United States
Cancer Care Center at Island Hospital

Anacortes, Washington, 98221, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Castle Medical Center

Kailua, Hawaii, 96734, United States
Central Illinois Hematology Oncology Center

Springfield, Illinois, 62702, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Columbus NCI Community Oncology Research Program

Columbus, Ohio, 43215, United States
Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Compass Oncology Vancouver

Vancouver, Washington, 98684, United States
Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States
Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, 66606, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Danville Regional Medical Center

Danville, Virginia, 24541, United States
Dayton NCI Community Oncology Research Program

Dayton, Ohio, 45459, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Delaware Radiation Oncology

Delaware, Ohio, 43015, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Evergreen Hematology and Oncology PS

Spokane, Washington, 99218, United States
FHCC at EvergreenHealth

Kirkland, Washington, 98034, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Franciscan Saint Francis Health-Beech Grove

Beech Grove, Indiana, 46107, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, 48532, United States
Glacier Oncology PLLC

Kalispell, Montana, 59901, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grandview Hospital

Dayton, Ohio, 45405, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greene Memorial Hospital

Xenia, Ohio, 45385, United States
Greenville Health System Cancer Institute-Andrews

Greenville, South Carolina, 29601, United States
Harborview Medical Center

Seattle, Washington, 98104, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Highlands Oncology Group - Rogers

Rogers, Arkansas, 72758, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Iredell Memorial Hospital

Statesville, North Carolina, 28677, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States
Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States
Kaiser Permanente Sacramento Medical Center

Sacramento, California, 95825, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente Washington

Seattle, Washington, 98112, United States
Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States
Kaiser Permanente-Fremont

Fremont, California, 94538, United States
Kaiser Permanente-Fresno

Fresno, California, 93720, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Redwood City

Redwood City, California, 94063, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-San Rafael

San Rafael, California, 94903, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Stockton

Stockton, California, 95210, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Matthews Radiation Oncology Center

Matthews, North Carolina, 28105, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106, United States
Minor and James Medical PLLC

Seattle, Washington, 98104, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Montana Cancer Consortium NCORP

Billings, Montana, 59102, United States
Montana Cancer Specialists

Missoula, Montana, 59802, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
Newark Radiation Oncology

Newark, Ohio, 43055, United States
Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, 30501, United States
Novant Health Cancer Institute - Huntersville

Huntersville, North Carolina, 28078, United States
Novant Health Cancer Institute - Matthews

Matthews, North Carolina, 28105, United States
Novant Health Cancer Institute - Mooresville

Mooresville, North Carolina, 28117, United States
Novant Health Carolina Surgical - Randolph

Charlotte, North Carolina, 28207, United States
Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States
OSF Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States
OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States
Oncology Hematology Care Inc-Anderson

Cincinnati, Ohio, 45230, United States
Oncology Hematology Care Inc-Blue Ash

Cincinnati, Ohio, 45242, United States
Oncology Hematology Care Inc-Crestview

Crestview Hills, Kentucky, 41017, United States
Oncology Hematology Care Inc-Eden Park

Cincinnati, Ohio, 45202, United States
Oncology Hematology Care Inc-Healthplex

Fairfield, Ohio, 45014, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Oncology Hematology Care Inc-Mercy West

Cincinnati, Ohio, 45211, United States
Oncology Specialists of Charlotte

Charlotte, North Carolina, 28207, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Providence Milwaukie Hospital

Milwaukie, Oregon, 97222, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Radiation Oncology of Northern Illinois

Ottawa, Illinois, 61350, United States
Reid Health

Richmond, Indiana, 47374, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rockwood Clinic

Spokane, Washington, 99220, United States
Rocky Mountain Oncology

Casper, Wyoming, 82609, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint Michael Cancer Center

Silverdale, Washington, 98383, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Singing River Hospital

Pascagoula, Mississippi, 39581, United States
Skagit Valley Hospital

Mount Vernon, Washington, 98274, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Southeast Clinical Oncology Research Consortium NCORP

Winston-Salem, North Carolina, 27104, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Southern Oncology Specialists-Charlotte

Charlotte, North Carolina, 28262, United States
Southern Oncology Specialists-Huntersville

Huntersville, North Carolina, 28078, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660, United States
Wellmont Medical Associates Oncology and Hematology-Bristol

Bristol, Tennessee, 37620, United States
Wellmont Medical Associates Oncology and Hematology-Johnson City

Johnson City, Tennessee, 37604, United States
Wenatchee Valley Hospital and Clinics

Wenatchee, Washington, 98801, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

Conditions

Explore the condition pages connected to this study.

EPITHELIOID MESOTHELIOMA PLEURAL MALIGNANT MESOTHELIOMA RECURRENT MALIGNANT MESOTHELIOMA SARCOMATOID MESOTHELIOMA