New antibody drug targets Hard-to-Treat cancers in early trial
NCT ID NCT06402201
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new drug called CDR404 in up to 42 adults with advanced solid tumors that have a specific marker (MAGE-A4) and tissue type (HLA-A*02:01). The drug is designed to help the body's immune T-cells find and attack cancer cells. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CDR404 (a bispecific antibody that engages T-cells to attack cancer cells)
What this could lead to
If it works, this could point toward a new treatment option for certain hard-to-treat solid tumors that express the MAGE-A4 protein.
What could go wrong
This is a very early, first-in-human trial with only 42 participants, so safety and effectiveness are not yet known. The treatment may cause side effects or fail to shrink tumors.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Cliniques Universitaires Saint-Luc, UCL Ouvain
RECRUITINGBrussels, 1200, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital Universitari Vall d'Hebron
RECRUITINGBarcelona, 08035, Spain
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Hospital Universitari i Politecnic La Fe
RECRUITINGValencia, 46026, Spain
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Institut Catala d'Oncologia, L'Hospitalet de Llobregat (ICO)
RECRUITINGBarcelona, 08908, Spain
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Institut Jules Bordet
RECRUITINGBrussels, 1070, Belgium
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Instituto de Investigacion Sanitaria (INCLIVA)
RECRUITINGValencia, 46026, Spain
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Isituto Europeo di Oncologia (IEO)
RECRUITINGMilan, 20141, Italy
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Istituto Clinico Humanitas
RECRUITINGMilan, 20089, Italy
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Pennsylvania Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19106, United States
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Providence Cancer Institute
RECRUITINGPortland, Oregon, 97213, United States
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Rigshospitalet
RECRUITINGCopenhagen, DK-2100, Denmark
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Royal Marsden Hospital
RECRUITINGSutton, London, SM2 5PT, United Kingdom
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START Madrid
RECRUITINGMadrid, 28050, Spain
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Universitair Ziekenhuis Antwerpen
RECRUITINGAntwerp, 2650, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitair Ziekenhuis Gent
RECRUITINGGhent, 9000, Belgium
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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