Kidney cancer patients may get a drug holiday thanks to new scan technique

NCT ID NCT07615348

Recruiting now Disease control Sponsor: Jinling Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 5 times

Summary

This study tests whether people with advanced kidney cancer can safely pause their medication after one year of treatment. Doctors will use a special PET scan that targets CD70 to decide who qualifies for a treatment break. The goal is to see if patients can stop drugs without the cancer coming back, improving their quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PD-1/PD-L1 inhibitor + VEGFR-TKI combination therapy
What this could lead to: If successful, this could allow some kidney cancer patients to take a break from treatment without the cancer growing back, improving quality of life.
What could go wrong: This is a small, early-phase trial with only 75 participants. The treatment holiday may not be safe for everyone, and cancer could progress during the break.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

clear cell renal carcinoma Clear-cell metastatic renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CLEAR CELL RENAL CELL CARCINOMA

Contacts and locations

Locations

Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University
RECRUITING

Nanjing, Jiangsu, 210000, China
Nanjing First Hospital, Nanjing Medical University
RECRUITING

Nanjing, Jiangsu, 210006, China
Sir Run Run Hospital, Nanjing Medical University
RECRUITING

Nanjing, Jiangsu, 211100, China
The First Affiliated Hospital of Nanjing Medical University
RECRUITING

Nanjing, Jiangsu, 210029, China
Wuxi No.2 People's Hospital (Jiangnan University Medical Center)
RECRUITING

Wuxi, Jiangsu, 214002, China

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