New drug aims to quiet MS brain lesions

NCT ID NCT04879628

Ongoing Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 15, 2026 · Updated 26 times

Summary

This study tests an experimental drug called SAR441344 in 129 adults with relapsing multiple sclerosis. The drug blocks a protein (CD40L) to reduce new active brain lesions seen on MRI. Participants receive either the drug or a placebo for several weeks. The goal is to see if the drug can control disease activity safely.

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Contacts and locations

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Locations

Center for Neurology and Spine- Site Number : 8400007

Phoenix, Arizona, 85032, United States
Investigational Site Number : 1000001

Sofia, 1407, Bulgaria
Investigational Site Number : 1000002

Pleven, 5809, Bulgaria
Investigational Site Number : 1000003

Sofia, 1113, Bulgaria
Investigational Site Number : 1240001

Gatineau, Quebec, J8Y 1W2, Canada
Investigational Site Number : 2030001

Jihlava, 58633, Czechia
Investigational Site Number : 2030002

Hradec Králové, 50005, Czechia
Investigational Site Number : 2030003

Brno, 65691, Czechia
Investigational Site Number : 2030004

Teplice, 415 29, Czechia
Investigational Site Number : 2030005

Ostrava - Poruba, 70852, Czechia
Investigational Site Number : 2500006

Calais, 62107, France
Investigational Site Number : 2760004

Münster, 48149, Germany
Investigational Site Number : 2760012

Leipzig, 04103, Germany
Investigational Site Number : 6430001

Moscow, 127015, Russia
Investigational Site Number : 6430002

Kazan', 420032, Russia
Investigational Site Number : 6430003

Saint Petersburg, 194044, Russia
Investigational Site Number : 6430004

Saint Petersburg, 197110, Russia
Investigational Site Number : 6430005

Saint Petersburg, 197022, Russia
Investigational Site Number : 6430006

Moscow, 117997, Russia
Investigational Site Number : 6430007

Moscow, 117556, Russia
Investigational Site Number : 6430008

Tyumen, 625000, Russia
Investigational Site Number : 7240002

Vigo, 36312, Spain
Investigational Site Number : 7240004

Barcelona, Barcelona [Barcelona], 08035, Spain
Investigational Site Number : 7920001

İzmit, 41380, Turkey (Türkiye)
Investigational Site Number : 7920002

Mersin, 33070, Turkey (Türkiye)
Investigational Site Number : 7920003

Istanbul, 34265, Turkey (Türkiye)
Investigational Site Number : 7920004

Eskişehir, 26040, Turkey (Türkiye)
Investigational Site Number : 8040002

Kyiv, 01135, Ukraine
Investigational Site Number : 8040003

Odesa, 65025, Ukraine
Investigational Site Number : 8040004

Lviv, 79013, Ukraine
Investigational Site Number : 8040005

Vinnytsia, 21001, Ukraine
Investigational Site Number : 8040006

Dnipro, 49089, Ukraine
Investigational Site Number : 8040008

Ivano-Frankivsk, 76493, Ukraine
Investigational Site Number : 8040010

Dnipro, 49005, Ukraine
Medical College of Wisconsin- Site Number : 8400006

Milwaukee, Wisconsin, 53226, United States
The Neurological Institute Site Number : 8400004

Charlotte, North Carolina, 28204, United States
University of South Florida Site Number : 8400001

Tampa, Florida, 33612, United States

Conditions

Explore the condition pages connected to this study.

MULTIPLE SCLEROSIS