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New hope for blood cancer patients: experimental drug CCS1477 enters human trials

NCT ID NCT04068597

Recruiting now Disease control Sponsor: CellCentric Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called CCS1477 (inobrodib) in people with advanced blood cancers like leukemia, lymphoma, and myeloma that have not responded to standard treatments. The drug is given as an oral capsule, either alone or combined with other cancer medicines. The goal is to see if it is safe and whether it can shrink tumors or improve outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CCS1477 (inobrodib) oral capsule, given alone or with other cancer drugs
What this could lead to
If successful, this could provide a new treatment option for people with advanced blood cancers that have stopped responding to standard therapies.
What could go wrong
This is an early-phase trial, so the drug may not work or could cause serious side effects. It is also a small study, so results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm mature T-cell and NK-cell non-Hodgkin lymphoma myelodysplastic syndrome non-Hodgkin lymphoma plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA HAEMATOLOGICAL MALIGNANCY HIGHER-RISK MYELODYSPLASTIC SYNDROME MULTIPLE MYELOMA NON-HODGKIN LYMPHOMA PERIPHERAL T-CELL LYMPHOMA

Contacts and locations

Locations

  • CIOCC Hospital Universitario HM Sanchinarro

    COMPLETED

    Madrid, 28050, Spain

  • Cancer and Haematology Centre

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Community Health Network

    RECRUITING

    Indianapolis, Indiana, 46227, United States

  • Emory Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Gartnavel General Hospital

    RECRUITING

    Glasgow, G12 0YN, United Kingdom

  • Gustave Roussy

    COMPLETED

    Villejuif, 94805, France

  • Hospital Clínic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Germans Trias i Pujol/ ICO Badalona

    RECRUITING

    Badalona, 08916, Spain

  • Hospital Infanta Leonor

    RECRUITING

    Madrid, 28031, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Gregorio Marañón

    RECRUITING

    Madrid, 28009, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario de La Princesa

    RECRUITING

    Madrid, 28006, Spain

  • Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana

    RECRUITING

    Valencia, 46026, Spain

  • ICO L'Hospitalet (Instituto Catalán de Oncología)

    RECRUITING

    Barcelona, 08908, Spain

  • Imperial College

    RECRUITING

    London, United Kingdom

  • Institute Bergonie

    COMPLETED

    Bordeaux, 33076, France

  • Karolinska Comprehensive Cancer Center

    COMPLETED

    Stockholm, Sweden

  • Leicester Royal Infirmary

    RECRUITING

    Leicester, United Kingdom

  • NIHR University College London Clinical Research Facility

    RECRUITING

    London, W1T 7HA, United Kingdom

  • Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68130, United States

  • Newcastle upon Tyne Hospitals

    RECRUITING

    Newcastle upon Tyne, United Kingdom

  • Nottingham University Hospitals NHS Trust

    RECRUITING

    Nottingham, NG5 1PB, United Kingdom

  • Penn Medicine - Abramson Cancer Center Perelman

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Royal Derby Hospital

    RECRUITING

    Derby, DE22 3NE, United Kingdom

  • Royal Stoke University Hospital

    RECRUITING

    Stoke-on-Trent, ST4 6QG, United Kingdom

  • Sarah Cannon Research Institute UK

    RECRUITING

    London, W1G 6AD, United Kingdom

  • St Bartholomew's Hospital

    RECRUITING

    London, EC1A 7BE, United Kingdom

  • The Center for Cancer and Blood Disorders (CCBD)

    RECRUITING

    Bethesda, Maryland, 20817, United States

  • The Christie Hospital

    RECRUITING

    Manchester, United Kingdom

  • The Clatterbridge Cancer Centre NHS Foundation Trust,

    RECRUITING

    Bebington, CH63 4JY, United Kingdom

  • The Royal Marsden

    RECRUITING

    Sutton, Surrey, SM2 5PT, United Kingdom

  • Universidad de Navarra

    RECRUITING

    Pamplona, 31008, Spain

  • University Hospital Vall D'Hebron

    COMPLETED

    Barcelona, 08035, Spain

  • University Hospital of Southampton

    RECRUITING

    Southampton, SO16 6YD, United Kingdom

  • University Hospital of Wales

    RECRUITING

    Cardiff, United Kingdom

  • University Hospitals Bristol

    RECRUITING

    Bristol, United Kingdom

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198-6846, United States

  • Western General Hospital

    RECRUITING

    Edinburgh, EH4 2XU, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.