New injection aims to soothe painful fat lumps

NCT ID NCT06303570

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether CBL-514 injections can reduce pain from lipomas in people with Dercum's disease. Nineteen adults with at least 4 painful lipomas will receive either the drug or a placebo. The main goal is to see if the treatment lowers pain scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CBL-514 injection

What this could lead to

If it works, this could point toward a non-surgical treatment to ease pain from Dercum's disease lipomas.

What could go wrong

This is a very small, early phase 2 study with only 19 people. The results may not apply to everyone, and the treatment might not work better than placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

adiposis dolorosa connective tissue disorder Lipedema Lipid Metabolism Disorders lipomatosis skin disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Investigator Site

    Spokane, Washington, 99204, United States