CBD shows promise for opioid craving and pain in tiny study
NCT ID NCT05076370
First seen Jan 03, 2026 · Last updated Jun 21, 2026 · Updated 22 times
Summary
This early-stage study tested whether cannabidiol (CBD) could safely help people with both opioid addiction and chronic pain. Seven adults on methadone or buprenorphine received different doses of CBD or a placebo in a controlled setting. Researchers measured sedation, cognitive function, side effects, and pain sensitivity to see if CBD might reduce cravings or pain without serious risks.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Veteran Affairs Hospital
West Haven, Connecticut, 06516, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cannabidiol (CBD)
What this could lead to
If it works, this could point toward a safe, non-addictive option to help manage pain and reduce opioid cravings in people already on medication for opioid addiction.
What could go wrong
This was a very small early-phase trial with only 7 participants, so results may not apply widely. CBD may cause sedation or other side effects, and it is not a standalone treatment for addiction.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.