Experimental CAR T-Cell therapy targets tough leukemias

NCT ID NCT07471789

Recruiting now Disease control Sponsor: Gyala Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing an experimental treatment called CART84 for people with acute myeloid leukemia (AML) or T-cell acute lymphoblastic leukemia (T-ALL) that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack leukemia cells. The study aims to find a safe dose and look for early signs that CART84 may help control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CART84 (GYA01), a CAR T-cell therapy made from the patient's own immune cells
What this could lead to: If it works, this could offer a new treatment option for people with hard-to-treat leukemias that have not responded to standard therapies.
What could go wrong: This is an early, small trial (33 people) focused on safety and dosing. The therapy may cause severe side effects or fail to control the leukemia. Success is not guaranteed.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T-cell acute lymphoblastic leukemia T-cell leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOBLASTIC LEUKAEMIA LEUKEMIA, T-CELL

Contacts and locations

Locations

Hospital Clínic de Barcelona
RECRUITING

Barcelona, Barcelona, 08036, Spain
Hospital Universitario y Politécnico La Fe
RECRUITING

Valencia, Valencia, 46026, Spain

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