Promising drug cocktail may halt smoldering myeloma before it starts

NCT ID NCT01572480

First seen Mar 20, 2026 · Last updated May 01, 2026 · Updated 9 times

Summary

This study tested whether a combination of three drugs (carfilzomib, lenalidomide, and dexamethasone) can safely stop smoldering multiple myeloma from turning into active cancer. Fifty-five adults with high-risk smoldering myeloma received eight cycles of the three drugs, followed by up to 12 more cycles of lenalidomide alone. The goal was to see if the treatment could clear all signs of cancer in the bone marrow.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike

    Bethesda, Maryland, 20892, United States

Conditions

Explore the condition pages connected to this study.