New nasal spray aims to tame relentless hunger in rare genetic disorder

NCT ID NCT06173531

Ongoing Symptom relief Sponsor: ACADIA Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This Phase 3 trial tests a nasal spray called carbetocin to reduce the intense, constant hunger (hyperphagia) in people with Prader-Willi syndrome. The study involves 170 participants aged 5 to 30 and lasts 12 weeks. Caregivers will rate changes in hunger-related behaviors using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

carbetocin nasal spray

What this could lead to

If it works, this could provide a new treatment to control the constant, severe hunger that is a hallmark of Prader-Willi syndrome.

What could go wrong

This is a Phase 3 trial, but it's still experimental. The drug may not work better than placebo, and side effects from the nasal spray are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Prader-Willi syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERPHAGIA IN PRADER-WILLI SYNDROME

Contacts and locations

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Locations

Alberta Diabetes Institute

Edmonton, Alberta, T6G 2E1, Canada
Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Barts Health NHS Trust - The Royal London Hospital

London, E1 1BB, United Kingdom
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
CHU Sainte Justine

Montreal, Quebec, H3T 1C5, Canada
Centre Hospitalier Universitaire (CHU) de Toulouse - Hôpital des Enfants

Toulouse, 31059, France
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Mercy Hospital

Kansas City, Missouri, 64108, United States
Children's of Alabama

Birmingham, Alabama, 35233, United States
Christus Children's

San Antonio, Texas, 78207, United States
Cook Children's Health Care System

Fort Worth, Texas, 79104, United States
Hospital General Universitario Gregorio Marañón

Madrid, 28009, Spain
Hospital Regional Universitario de Málaga

Málaga, 29010, Spain
KJF Klinik Josefinum gGmbH

Augsburg, 86154, Germany
Maimonides Medical Center

Brooklyn, New York, 11219, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Parc Taulí Hospital Universitari

Barcelona, 08208, Spain
Phoenix Children's Hospital

Phoenix, Arizona, 85006, United States
Rady Children's Hospital San Diego

San Diego, California, 92123, United States
Royal Hospital for Children Glasgow Clinical Research Facility

Glasgow, G51 4TF, United Kingdom
SSM Health/Saint Louis University

St Louis, Missouri, 63104, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Stanford University School of Medicine

Palo Alto, California, 94304, United States
UPMC-Children's Hospital Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital

Birmingham, B9 5SS, United Kingdom
University of California Irvine

Orange, California, 92697, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Utah

Salt Lake City, Utah, 84108, United States
Universitätsklinikum Essen

Essen, 45147, Germany
Vanderbilt Clinical Research Center

Nashville, Tennessee, 37232, United States