Revolutionary CAR-T therapy battles Tough-to-Treat blood cancer in major trial

NCT ID NCT04181827

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new personalized immune cell therapy (called cilta-cel) works better than current standard drug combinations for people with multiple myeloma that has come back and is resistant to a common treatment. About 419 participants whose cancer has progressed after 1-3 prior therapies will be randomly assigned to receive either the new CAR-T therapy or one of two standard drug regimens. The main goal is to see which treatment keeps the cancer from getting worse for the longest time.

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Contacts and locations

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Locations

A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette

Turin, 10126, Italy
Akademiska Sjukhuset

Uppsala, 751 85, Sweden
Alfred Health

Melbourne, 3004, Australia
Attikon University General Hospital of Attica

Athens, 12462, Greece
Azienda Opedaliero-Universitaria Policlinico Sant'orsola Malpighi di Bologna

Bologna, 40138, Italy
Bristol Haematology and Oncology Centre

Bristol, BS2 8ED, United Kingdom
C.H.U. Hotel Dieu - France

Nantes, 44093, France
CHRU de Lille Hopital Claude Huriez

Lille, 59037, France
CHU De Poitiers

Poitiers, 86021, France
CHU de Montpellier Hopital Saint Eloi

Montpellier, 34295, France
Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman

Liège, B-4000, Belgium
Christie Hospital

Manchester, M20 4BX, United Kingdom
Clinica Univ. de Navarra

Pamplona, 31008, Spain
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Erasmus MC

Rotterdam, 3015 CN, Netherlands
Fiona Stanley Hospital

Murdoch, 6150, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy
Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hadassah University Hospita Ein Kerem

Jerusalem, P.O.B. 12000, Israel
Hokkaido University Hospital

Sapporo, 060-8648, Japan
Hopital Saint Louis

Paris, 75475, France
Hosp Clinic de Barcelona

Barcelona, 08036, Spain
Hosp Clinico Univ de Salamanca

Salamanca, 37007, Spain
Hosp. Gral. Univ. Gregorio Maranon

Madrid, 28007, Spain
Hosp. Univ. 12 de Octubre

Madrid, 28041, Spain
Hosp. Virgen Del Rocio

Seville, 41013, Spain
Hospices Civils de Lyon HCL

Lyon, 69002, France
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
IRCCS Ospedale San Raffaele HSR

Milan, 20132, Italy
Inst. Cat. D'Oncologia-Badalona

Badalona, 08916, Spain
Institut Universitaire du cancer de Toulouse-Oncopole

Toulouse, 31059, France
Instytut Hematologii i Transfuzjologii

Warsaw, 02 776, Poland
Japanese Red Cross Medical Center

Shibuya City, 150-8935, Japan
Kanazawa University Hospital

Kanazawa, 920 8641, Japan
Karolinska Universitetssjukhuset Huddinge, Hematologiska Kliniken, Huddinge

Stockholm, 141 86, Sweden
Kings College Hospital

London, SE5 9RS, United Kingdom
Klinikum der Eberhard Karls Universitaet Abt fur innere Med II Haematologie Onkologie Germany

Tübingen, 72076, Germany
Kyushu University Hospital

Fukuoka, 812 8582, Japan
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
Mayo Clinic Cancer Center-Scottsdale

Phoenix, Arizona, 85054, United States
Medical College Of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States
Nagoya City University Hospital

Nagoya, 467 8602, Japan
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach

Gliwice, 44102, Poland
Okayama University Hospital

Okayama, 700 8558, Japan
Peter MacCallum Cancer Centre

Melbourne, 3000, Australia
Policlinico Universitario Agostino Gemelli

Roma, 00168, Italy
Queen Elizabeth Hospital

Birmingham, B15 2TH, United Kingdom
Rigshospitalet

Copenhagen, DK-2100, Denmark
Royal Adelaide Hospital

Adelaide, 5000, Australia
Royal Brisbane and Womens Hospital

Herston, 4029, Australia
Royal Prince Alfred Hospital

Camperdown, 2050, Australia
Samsung Medical Center

Seoul, 06351, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Sheba Medical Center

Ramat Gan, 74047, Israel
Skane University Hospital

Lund, 221 85, Sweden
Sourasky Medical Center

Tel Aviv, 64239, Israel
Stanford University Medical Center

Stanford, California, 94305-5623, United States
The Catholic University of Korea Seoul St Marys Hospital

Seoul, 06591, South Korea
The Ohio State University

Columbus, Ohio, 43210, United States
Tohoku University Hospital

Sendai, 980 8574, Japan
UMC Utrecht

Utrecht, 3584 CX, Netherlands
UZ Gent

Ghent, 9000, Belgium
UZ Leuven

Leuven, 3000, Belgium
Universitaetsklinikum Hamburg Eppendorf

Hamburg, 20246, Germany
Universitaetsklinikum Koeln

Cologne, 50924, Germany
Universitaetsklinikum Leipzig

Leipzig, 04103, Germany
Universitair Ziekenhuis - Antwerpen

Antwerp, 2650, Belgium
Universitatsklinikum Carl Gustvav Carus Dresden an der Technischen Universitat Dresden

Dresden, 01307, Germany
Universitatsklinikum Wurzburg

Würzburg, 97080, Germany
University College Hospital

London, NW1 2BU, United Kingdom
University Hospital Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan
University Hospital Wales

Cardiff, CF14 4XW, United Kingdom
University Medical Center Groningen

Groningen, 9713 GZ, Netherlands
University Of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University Of Miami Leonard M Mille School Of Medicine SCCC

Miami, Florida, 33136, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas

Westwood, Kansas, 66205, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
Uniwersytecki Szpital Kliniczny w Poznaniu

Poznan, 60-569, Poland
Uniwersyteckie Centrum Kliniczne

Gdansk, 80 214, Poland
VU Medisch Centrum

Amsterdam, 1081 HV, Netherlands
Washington University School Of Medicine

St Louis, Missouri, 63110, United States
Wisconsin Institutes for Medical Research

Madison, Wisconsin, 53705, United States
Yale New Haven Hospital

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

MULTIPLE MYELOMA