New 'Sandwich' therapy aims to stop leukemia relapse after transplant

NCT ID NCT06985498

First seen Mar 28, 2026 · Last updated May 02, 2026 · Updated 3 times

Summary

This study tests a new treatment plan for young adults and adults with B-cell acute lymphoblastic leukemia (B-ALL). The approach uses immunotherapy before an autologous stem cell transplant, followed by a 'sandwich' of two types of CAR-T cells (CD22 and CD19) to try to prevent the cancer from coming back. The goal is to see if this strategy is safe and helps people live longer without leukemia returning. About 40 participants will be enrolled.

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