One-Shot immune reset: early trial tests CAR-T therapy for debilitating muscle disease
NCT ID NCT06359041
Summary
This early-phase study is testing an investigational one-time cell therapy called CABA-201 in adults with generalized myasthenia gravis (gMG), a rare autoimmune disease that causes severe muscle weakness. The therapy aims to reset the immune system by removing the harmful B cells thought to drive the disease. Researchers will primarily check if the treatment is safe and will also measure if it helps improve patients' daily function and muscle strength.
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Contacts and locations
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Locations
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Baylor College of Medicine Neurology Department
Houston, Texas, 77030, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Columbia University
New York, New York, 10032, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Swedish Neuroscience Research
Seattle, Washington, 98122, United States
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UC Davis, Department of Neurology
Sacramento, California, 95817, United States
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University of California Irvine
Orange, California, 92868, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Massachusetts Chan Medical School
Worcester, Massachusetts, 01655, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
Explore the condition pages connected to this study.