Can a burst of radiation make CAR t-cells fight cancer harder?
NCT ID NCT07725406
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether adding a small dose of total body radiation to standard CAR T-cell therapy can help the immune cells grow stronger and last longer in the body. It enrolls adults with relapsed or hard-to-treat diffuse large B-cell lymphoma or multiple myeloma who are already scheduled to receive a commercial CAR T-cell product. The goal is to see if the combination is safe and can improve the cancer-killing response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-dose total body irradiation added to standard CAR T-cell therapy (CD19 or BCMA-directed)
- What this could lead to
- If successful, this approach could make CAR T-cell therapy more effective and durable for patients with hard-to-treat blood cancers.
- What could go wrong
- This is an early-phase, dose-escalation trial with only 32 participants, so safety and effectiveness are not yet established. Adding radiation may increase side effects like cytokine release syndrome or bone marrow suppression.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Weill Cornell Medicine/NewYork-Presbyterian Hospital
New York, New York, 10065, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••