Scientists test 'Living Drug' to reset immune system in devastating autoimmune diseases

NCT ID NCT06544330

Summary

This is an early-stage safety study testing a new two-part cell therapy for people with severe autoimmune diseases like lupus and scleroderma that haven't responded to other treatments. Doctors will collect a patient's own immune cells, genetically modify them to target a specific protein (CD19), and infuse them back, followed by a supporting drug (STK-009). The main goal is to see if this combination is safe and tolerable, while also checking if it helps control the disease.

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Contacts and locations

Locations

  • Feinstein Institutes for Medical Research

    Manhasset, New York, 11030, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • HonorHealth Research Institute

    Scottsdale, Arizona, 85258, United States

  • Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

Conditions

Explore the condition pages connected to this study.