One-Shot cell therapy aims to reset immune system in debilitating muscle disease
NCT ID NCT06359041
First seen Nov 01, 2025 · Last updated Apr 20, 2026 · Updated 20 times
Summary
This early-stage study is testing a single dose of an investigational cell therapy called CABA-201 for adults with generalized myasthenia gravis (gMG), a rare autoimmune disease that causes severe muscle weakness. The therapy involves collecting a patient's own immune cells, modifying them to target the B cells believed to drive the disease, and reinfusing them after a short course of chemotherapy. The main goals are to see if the treatment is safe and if it can reduce disease symptoms and autoantibodies.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baylor College of Medicine Neurology Department
Houston, Texas, 77030, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Columbia University
New York, New York, 10032, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Swedish Neuroscience Research
Seattle, Washington, 98122, United States
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UC Davis, Department of Neurology
Sacramento, California, 95817, United States
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University of California Irvine
Orange, California, 92868, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Massachusetts Chan Medical School
Worcester, Massachusetts, 01655, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Conditions
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