New CAR-T therapy targets tough childhood cancers
NCT ID NCT06508931
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a new type of CAR-T cell therapy called MB-CART2019.1 in children and teens (ages 6 months to under 18) with B-cell cancers that have come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to attack cancer cells carrying two markers (CD20 and CD19). The study aims to see how well it shrinks tumors and to monitor side effects. About 31 participants will be enrolled across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
zamtocabtagene autoleucel (MB-CART2019.1), a type of CAR-T cell therapy that targets two proteins (CD20 and CD19) on cancer cells
What this could lead to
If this works, it could offer a new treatment option for children with aggressive B-cell cancers that have not responded to other therapies.
What could go wrong
This is a small, early-phase trial with only 31 participants, so results may not apply to everyone. CAR-T therapy can cause serious side effects like cytokine release syndrome or neurological problems.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hôpital Robert Debré
ACTIVE_NOT_RECRUITINGParis, Boulevard Sérurier 48, 75019, France
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IRCCS Ospedale Pediatrico Bambino Gesù
RECRUITINGRome, Piazza Sant Onofrio 4, 00165, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Gustave Roussy
RECRUITINGVillejuif, 94805, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Prinses Maxima Centrum
ACTIVE_NOT_RECRUITINGUtrecht, Heidelberglaan 25, Netherlands
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Universitaetsklinikum Muenster (UKM) - Klinik fuer Kinder- und Jugendmedizin - Paediatrische Haematologie und Onkologie
ACTIVE_NOT_RECRUITINGMünster, Albert-Schweitzer-Campus 1, Gebaeude A1, 48129, Germany