New chemo drug could mean fewer shots for kids with blood cancer

NCT ID NCT01574274

First seen Feb 05, 2026 · Last updated Apr 28, 2026 · Updated 12 times

Summary

This study compares a new form of chemotherapy (calaspargase pegol) given every 3 weeks to the standard form (Oncaspar) given every 2 weeks in children and teens with acute lymphoblastic leukemia or lymphoblastic lymphoma. The goal is to see if the new drug has similar side effects and drug levels, and if adjusting treatment based on early cancer cell levels can improve cure rates. The study also tests giving antibiotics early to prevent serious infections and looks at vitamin D levels to reduce bone problems.

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Contacts and locations

Locations

  • Centre Hospitalier U. de Quebec

    Québec, Quebec, Canada

  • Children's Hospital Boston

    Boston, Massachusetts, 02215, United States

  • Columbia University Medical Center, Morgan Stanley Children's Hospital of New York-Presbyterian

    New York, New York, 10032, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Hasbro Children's Hospital

    Providence, Rhode Island, 02903, United States

  • Hospital Sainte Justine, University of Montreal

    Montreal, Quebec, Canada

  • McMaster University

    Hamilton, Ontario, Canada

  • Montefiore Medical Center

    New York, New York, 10467, United States

Conditions

Explore the condition pages connected to this study.