New antibody aims to clear deadly protein clogs from Patients' hearts and organs

NCT ID NCT04512235

Ongoing Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding an experimental antibody called CAEL-101 to standard treatment helps people with a serious stage of AL amyloidosis, a disease where abnormal proteins build up and damage organs like the heart. The antibody is designed to help clear these harmful protein deposits from tissues. Researchers will measure if this approach helps patients live longer, reduces heart-related hospital stays, and improves their quality of life.

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Contacts and locations

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Locations

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Scottsdale, Arizona, 85259, United States
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Duarte, California, 91010, United States
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Palo Alto, California, 94304, United States
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San Francisco, California, 94143, United States
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Jacksonville, Florida, 32224, United States
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Weston, Florida, 33331, United States
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Indianapolis, Indiana, 46202, United States
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New Orleans, Louisiana, 70112, United States
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Baltimore, Maryland, 21201, United States
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Boston, Massachusetts, 02111, United States
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Boston, Massachusetts, 02118, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48201, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Rochester, New York, 14642, United States
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Chapel Hill, North Carolina, 27599, United States
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Durham, North Carolina, 27705, United States
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Winston-Salem, North Carolina, 27157, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Portland, Oregon, 97239, United States
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Philadelphia, Pennsylvania, 19104, United States
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Nashville, Tennessee, 37232, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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Salt Lake City, Utah, 84112, United States
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Seattle, Washington, 98109, United States
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Madison, Wisconsin, 53792, United States
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Milwaukee, Wisconsin, 53226, United States
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Box Hill, 3128, Australia
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Murdoch, WA6150, Australia
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Westmead, 2145, Australia
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Woolloongabba, 4102, Australia
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Linz, 4020, Austria
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Vienna, 1090, Austria
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Anderlecht, 1070, Belgium
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Leuven, 3000, Belgium
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Porto Alegre, 90110-270, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Salvador, 41253-190, Brazil
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Calgary, Alberta, T2N 4N2, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Beijing, 100034, China
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Beijing, 100730, China
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Guangzhou, 510180, China
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Hangzhou, 310009, China
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Shanghai, 200032, China
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Suzhou, 215006, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Ostrava Poruba, 708 52, Czechia
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Prague, 12808, Czechia
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Caen, 14033, France
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Créteil, 94000, France
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Dijon, 21079, France
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Lille, 59037, France
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Limoges, 87042, France
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Marseille, 13009, France
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Paris, 75010, France
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Pessac, 33604, France
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Pierre-Bénite, 69310, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Toulouse, 31100, France
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Tours, 37044, France
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Berlin, 12203, Germany
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Düsseldorf, 40225, Germany
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Essen, 45147, Germany
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Hamburg, 22767, Germany
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Heidelberg, 69120, Germany
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Würzburg, 97080, Germany
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Athens, 11528, Greece
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Rio, 26504, Greece
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Thessaloniki, 54636, Greece
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Haifa, 31096, Israel
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Jerusalem, 91120, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 64239, Israel
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Tel Litwinsky, 52621, Israel
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Brescia, 25123, Italy
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Fukushima, 960-1295, Japan
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Kanazawa, 920-8641, Japan
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Kashiwa-shi, 277-8567, Japan
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Kita-ku, 603-8151, Japan
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Kumamoto, 860-8556, Japan
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Matsumoto-shi, 390-8621, Japan
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Nagoya, 467-8602, Japan
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Shibuya-ku, 150-8935, Japan
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Gdansk, 80-214, Poland
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Warsaw, 01-748, Poland
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Saint Petersburg, 197022, Russia
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Barcelona, 08036, Spain
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Barcelona, 8035, Spain
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Gijón, 33394, Spain
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Granada, 18014, Spain
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Madrid, 28003, Spain
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Madrid, 28040, Spain
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Majadahonda, 28222, Spain
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Pamplona, 31008, Spain
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Salamanca, 37007, Spain
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Seville, 41013, Spain
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Valencia, 46009, Spain
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Glasgow, G12 0YN, United Kingdom
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London, NW1 2PG, United Kingdom

Conditions

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AL AMYLOIDOSIS