Brain's nighttime cleanup crew gets a boost in fight against dangerous protein buildup

This study is testing whether improving sleep or stimulating a neck nerve can help the brain's natural cleaning system remove harmful amyloid proteins in people with cerebral amyloid angiopathy (CAA). Sixty participants with different types of CAA will receive either a sleep medication, non-invasive nerve stimulation, or both, to see if these approaches enhance protein clearance. Researchers will measure protein levels in spinal fluid and use advanced brain imaging to track changes in disease markers and the brain's cleaning activity.