Rural opioid treatment breakthrough: monthly shot vs. daily pills

NCT ID NCT06023459

First seen Jan 11, 2026 · Last updated Apr 24, 2026 · Updated 11 times

Summary

This study tests whether a once-monthly injection of buprenorphine works as well as daily buprenorphine-naloxone pills for people with opioid use disorder living in rural areas. About 144 adults will be randomly assigned to one of the two treatments for 14 weeks. The goal is to see if the monthly shot is practical and acceptable in rural clinics, and whether it helps reduce opioid use.

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Contacts and locations

Locations

  • AppleGate Recovery El Dorado

    El Dorado, Arkansas, 71730, United States

  • Gibson Area Hospital and Health Services - Gibson Recovery Optimizing Wellness

    Gibson City, Illinois, 60936, United States

  • New Beginnings Recovery Clinic & Behavioral Health Center

    New Martinsville, West Virginia, 26155, United States

  • Oregon Health & Science University Primary Care Clinic, Scappoose

    Scappoose, Oregon, 97056, United States

  • Penobscot Community Health Care Inc. - Seaport Community Health Center

    Belfast, Maine, 04915, United States

  • Providence Northeast Washington Medical Group

    Colville, Washington, 99114, United States

  • Southern Humboldt Community Healthcare District - Jerold Phelps Community Hospital

    Garberville, California, 95542, United States

Conditions

Explore the condition pages connected to this study.