New hope for rare blistering disease: drug may tame pemphigus without high steroid doses

NCT ID NCT06696716

First seen Nov 19, 2025 · Last updated May 15, 2026 · Updated 23 times

Summary

This study tests an experimental drug called ONO-4059 for people with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. It is for patients whose disease is not well controlled by steroids alone. The goal is to see if adding ONO-4059 can help achieve lasting remission while allowing lower steroid doses. About 34 adults will participate in this Phase 3 trial.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ehime University Hospital

    RECRUITING

    Ehime, Japan

  • Fukushima Medical University Hospital

    RECRUITING

    Fukushima, Japan

  • Gunma University Hospital

    RECRUITING

    Gunma, Japan

  • Hokkaido University Hospital

    RECRUITING

    Hokkaido, Japan

  • Ichinomiya Municipal Hospital

    RECRUITING

    Aichi, Japan

  • Jichi Medical University Hospital

    RECRUITING

    Tochigi, Japan

  • Kagoshima University Hospital

    RECRUITING

    Kagoshima, Japan

  • Kawasaki Medical School Hospital

    RECRUITING

    Okayama, Japan

  • Keio University Hospital

    RECRUITING

    Tokyo, Japan

  • Kindai university hospital

    RECRUITING

    Osaka, Japan

  • Kumamoto University Hospital

    RECRUITING

    Kumamoto, Japan

  • Kurume University Hospital

    RECRUITING

    Fukuoka, Japan

  • Nagoya City University Hospital

    RECRUITING

    Aichi, Japan

  • Niigata University Medical & Dental Hospital

    RECRUITING

    Niigata, Japan

  • Osaka Metropolitan University Hospital

    RECRUITING

    Osaka, Japan

  • Saitama Medical Center

    RECRUITING

    Saitama, Japan

  • Shiga University of Medical Science Hospital

    RECRUITING

    Shiga, Japan

  • St.Marianna University School of Medicine Hospital

    RECRUITING

    Kanagawa, Japan

  • Tokai University Hospital

    RECRUITING

    Kanagawa, Japan

  • Tokyo Medical and Dental University Hospital

    RECRUITING

    Tokyo, Japan

  • Tokyo Women's Medical University Hospital

    RECRUITING

    Tokyo, Japan

  • University Hospital Kyoto Prefectural University of Medicine

    RECRUITING

    Kyoto, Japan

  • University of the Ryukyus Hospital

    RECRUITING

    Okinawa, Japan

  • Yamagata University Hospital

    NOT_YET_RECRUITING

    Yamagata, Japan

  • Yokohama City University Hospital

    RECRUITING

    Kanagawa, Japan

Conditions

Explore the condition pages connected to this study.