Head-to-Head showdown: which drug works better against tough lung cancer?

NCT ID NCT03596866

Summary

This study compared two oral medications, brigatinib and alectinib, for people with advanced ALK-positive lung cancer whose cancer had worsened while taking their first targeted therapy. The trial involved 248 participants worldwide who were randomly assigned to receive one of the two drugs to see which better controlled cancer growth and improved survival. Researchers measured how long each drug kept the cancer from progressing and monitored quality of life and side effects over up to five years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Affiliated Tumor Hospital of Harbin Medical University - The 3rd Affiliated Hospital of HMU

    Harbin, Heilongjiang, 150081, China

  • Ajou University Hospital

    Suwon, Gyeonggi-do, 16499, South Korea

  • Asklepios Fachkliniken Munchen-Gauting

    Gauting, Bavaria, 82131, Germany

  • Azienda Ospedaliera Universitaria San Martino

    Genova, 16132, Italy

  • Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi

    Bologna, 40138, Italy

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality, 100142, China

  • Beijing Chest Hospital

    Beijing, Beijing Municipality, 100000, China

  • Center of Palliative Medicine - Devita

    Saint Petersburg, 197343, Russia

  • Centre Hospitalier Intercommunal Toulon - La Seyne Sur Mer

    Toulon, Provence-Alpes-Côte d'Azur Region, 83056, France

  • Centre Hospitalier Intercommunal de Creteil

    Créteil, Île-de-France Region, 94010, France

  • Centre Hospitalier Le Mans

    Le Mans, Pays de la Loire Region, 72037, France

  • Centre Hospitalier Universitaire de Toulouse- Hopital Larrey

    Toulouse, Midi-pyrenees, 31059, France

  • Centro Oncologico Riojano Integral

    La Rioja, F5300COE, Argentina

  • Centro Para la Atencion Integral del Paciente Oncologico

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Centro de Investigacion Clinica Bradford Hill

    Recoleta, Santiago Metropolitan, 76894, Chile

  • Centro de Investigacion Medica Aguascalientes

    Aguascalientes, 20116, Mexico

  • Centro di Riferimento Oncologico di Aviano

    Aviano, Pordenone, 33081, Italy

  • Centrul de oncologie Euroclinic

    Iași, 700106, Romania

  • Chang Gung Memorial Hospital Linkou Branch

    Tianjin, Tianjin Municipality, 300060, China

  • Chang Gung Memorial Hospital Linkou Branch

    Taoyuan, 333, Taiwan

  • Changhua Christian Hospital

    Changhua, 500, Taiwan

  • Chi Mei Hospital Liouying

    Tainan, 73657, Taiwan

  • Chungbuk National University Hospital

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Clinica Ultra Sound Diagnostic 4D

    Pyatigorsk, Stavropol Kray, 357502, Russia

  • Euromedservice

    Saint Petersburg, Sankt-Peterburg, 196603, Russia

  • Fudan University Shanghai Cancer Center

    Dubrovnik, Dubrovnik-Neretva County, 20 000, Croatia

  • Fudan University Shanghai Cancer Center

    Créteil, Île-de-France Region, 94010, France

  • Gachon University Gil Medical Center

    Incheon, Gyeonggi-do, 21565, South Korea

  • General Hospital Pula

    Pula, 52100, Croatia

  • General Oncology Hospital of Kifisia Oi Agioi Anargiroi

    Nea Kifissia, Attica, 14564, Greece

  • Gustave Roussy

    Villejuif, Île-de-France Region, 94805, France

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450008, China

  • Hong Kong United Oncology Centre

    Kowloon, Hong Kong

  • Hopital Albert Michallon

    Grenoble, Auvergne-Rhône-Alpes, 38043, France

  • Hopital Foch

    Suresnes, Île-de-France Region, 92151, France

  • Hopital Haut-Leveque

    Pessac, Aquitaine, 33604, France

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007, Spain

  • Hospital Regional Universitario de Malaga

    Málaga, 29010, Spain

  • Hospital Teresa Herrera - Materno Infantil

    A Coruña, LA Coruna, 15006, Spain

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Hospital Universitari Sant Joan de Reus

    Reus, 43204, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Ramon Y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hualien Tzu Chi Hospital

    Hualien City, 970, Taiwan

  • Humanity and Health Research Centre

    Central, Hong Kong

  • Iaso General Hospital

    Cholargós, Attica, 15562, Greece

  • Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucaresti

    Bucharest, 022328, Romania

  • Institutul Oncologic Prof. Dr. Ion Chiricu

    Cluj-Napoca, Cluj, 400015, Romania

  • Interbalkan Medical Center of Thessaloniki

    Thessaloniki, Macedonia, 57001, Greece

  • Irkutsk Regional Oncology Center

    Irkutsk, 664035, Russia

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale

    Naples, 80131, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

    Meldola, Forli-cesena, 47014, Italy

  • Istituto Scientifico Universitario San Raffaele

    Milan, 20132, Italy

  • Jilin Provincial Cancer Hospital (Changchun Cancer Hospital)

    Changchun, Jilin, 13000, China

  • Kaohsiung Medical University Hospital

    Kaohsiung City, 807, Taiwan

  • Karolinska Universitetssjukhuset - Solna

    Solna, Stockholm County, 171 64, Sweden

  • King Chulalongkorn Memorial Hospital

    Bangkok, Bangkok Metropolis, 10330, Thailand

  • Klinicki bolnicki centar Sestre milosrdnice

    Zagreb, 10000, Croatia

  • Klinika za Pulmologiju

    Zagreb, 10000, Croatia

  • Klinikum Kempten-Oberallgau

    Immenstadt im Allgäu, Bavaria, 87509, Germany

  • Klinikum Klagenfurt Am Worthersee

    Klagenfurt, Carinthia, 9020, Austria

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Leningrad Regional Clinical Hospital

    Saint Petersburg, 194291, Russia

  • Medica Sur

    Mexico City, Mexico City, 14050, Mexico

  • Moscow City Oncology Hospital Number 62

    Moscow, 143423, Russia

  • N.N. Blokhin Russian Cancer Research Center

    Moscow, 115478, Russia

  • National Cancer Center

    Goyang-si, Gyeonggi-do, 10408, South Korea

  • National Cheng Kung University Hospital

    Tainan, 70403, Taiwan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • New York Oncology Hematology - Albany Medical Center

    Albany, New York, 12208, United States

  • Omsk Regional Clinical Oncologic Dispensary

    Omsk, 644013, Russia

  • Oncocenter- Oncologie Clinica

    Timișoara, Timiș County, 300166, Romania

  • Opca bolnica Dubrovnik

    Dubrovnik, Dubrovnik-Neretva County, 20 000, Croatia

  • Ospedale Santa Maria delle Croci

    Ravenna, 48121, Italy

  • Pamela Youde Nethersole Eastern Hospital

    Chai Wan, Eastern District, 999077, Hong Kong

  • Peking Union Medical College Hospital - East

    Beijing, Beijing Municipality, 100032, China

  • Peking University Cancer Hospital/Beijing Cancer Hospital

    Beijing, Beijing Municipality, 100036, China

  • Phramongkutklao Hospital

    Bangkok, Bangkok Metropolis, 10400, Thailand

  • Princess Margaret Hospital

    Kowloon, Hong Kong

  • Queen Elizabeth II Health Sciences Centre

    Halifax, Nova Scotia, B3H 1V7, Canada

  • Queen Mary Hospital

    Hong Kong, 00852, Hong Kong

  • Queen Mary Hospital

    Hong Kong, Hong Kong

  • Saint Petersburg Clinical Scientific and Practical Center of Specialized Types of Medical Aid

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Saint Petersburg State Healthcare Institution Municipal Clinical Oncology Dispensary

    Saint Petersburg, 197758, Russia

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sanatorio Duarte Quiros

    Córdoba, 5000, Argentina

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shanghai Chest Hospital

    Shanghai, Shanghai Municipality, 200030, China

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • Sotiria General Hospital for Respiratory Diseases of Attica

    Athens, 11527, Greece

  • State Budget Institution National Medical Research Center of Radiology of the Ministry of Heal

    Moscow, 125284, Russia

  • State Institution of Healthcare Arkhangelsk Regional Clinical Oncology Dispensary

    Arkhangelsk, Arkhangelr, 163045, Russia

  • The 307th Hospital of Chinese Peoples Liberation Army

    Beijing, Beijing Municipality, 100071, China

  • The Catholic University of Korea - Seoul St. Mary's Hospital

    Seoul, 06591, South Korea

  • The Catholic University of Korea St. Vincent's Hospital

    Suwon, Gyeonggi-do, 16247, South Korea

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, 510120, China

  • The First Affiliated Hospital, Zhejiang University

    Hangzhou, Zhejiang, 31000, China

  • The Oncology Institute of Hope and Innovation

    Whittier, California, 90602, United States

  • Thoraxklinik Heidelberg

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, Tianjin Municipality, 300060, China

  • Toronto University Health Network

    Toronto, Ontario, M5G 2M9, Canada

  • Ulsan University Hospital

    Ulsan, Gyeongsangnam-do, 44033, South Korea

  • University Cancer and Blood Center

    Athens, Georgia, 30607, United States

  • University General Hospital of Athens Attikon

    Athens, Attica, 12462, Greece

  • University General Hospital of Larissa

    Larissa, Thessaly, 41110, Greece

  • Uppsala Akademiska Sjukhus

    Uppsala, 751 85, Sweden

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

  • VitaMed

    Moscow, 121309, Russia

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310003, China

Conditions

Explore the condition pages connected to this study.